ABSTRACT This study demonstrates the application of a model based meta analysis (MBMA) framework to characterize the safety and efficacy profiles of therapies in relapsed and refractory multiple myeloma (RRMM). Published clinical trial data were analyzed to evaluate the incidence of Grade ≥ 3 neutropenia and overall response rate (ORR), providing a ...
Zeel Shah +8 more
wiley +1 more source
Caregiver recruitment and engagement: identifying best practices and strategies for including family caregivers of veterans in health services research. [PDF]
Ngo V +10 more
europepmc +1 more source
Clinical and Molecular Effect of the Anti–IL‐18 Antibody Aletekitug in Adults With Atopic Dermatitis
At Week 12, aletekitug was associated with a −68.3% percentage change from baseline in EASI score. Aletekitug improved the transcriptional profile of lesional skin towards that of non‐lesional skin at Week 4 and Week 12. Aletekitug was well‐tolerated; no serious adverse event or death occurred, and no patient withdrew due to an adverse event.
Joanne Ellis +32 more
wiley +1 more source
Identification of typical marker proteins of Treponema pallidum in compact human bone using morphological and biochemical techniques. [PDF]
Schmidt Schultz TH, Schultz M.
europepmc +1 more source
Shades of empire: Evidence from Swedish and Polish–Lithuanian partitions in the Baltics
Abstract In this study, we explore the long‐run effects of Swedish and Polish–Lithuanian imperial legacies in the Baltic region. Using a robust regression discontinuity design, we identify persistent differences in socio‐economic development across the South Livonia–Courland and the South Livonia–Lettgallia borders that emerged as a result of the ...
Theocharis N. Grigoriadis, Alise Vitola
wiley +1 more source
Morbidity and Mortality Profile of Leishmaniasis in an Andean Region of Ecuador in the Context of Climate Change. [PDF]
Páez-Espinosa EV +6 more
europepmc +1 more source
Abstract This article investigates the impact of local political institutions on inequality in eastern England between c. 1350 and c. 1550. Specifically, it examines the extent to which wealthier individuals controlled local governance structures in the form of manor courts through linking the identities of individuals who served as manorial officials ...
Spike Gibbs
wiley +1 more source
Functionality and performance of COVID-19 taskforces in response to the pandemic in Uganda. [PDF]
Musoke D +8 more
europepmc +1 more source
Child labour and industrialization: Evidence from factory records and the 1851 British census
Abstract Children were an integral part of the workforce during the British Industrial Revolution. The changing patterns of child labour as well as the causes behind its rise and fall have generated much scholarly debate. This study brings in new direct evidence on child labour from children's age certificates and school attendance records from cotton ...
Xuesheng You, Alexander Tertzakian
wiley +1 more source

