Results 161 to 170 of about 2,049,123 (312)

Park Improvements and Park Activity [PDF]

open access: yesAmerican Journal of Preventive Medicine, 2012
Jenny Veitch   +4 more
openaire   +1 more source

Reasons in Favor of the Establishment of a National Park

open access: yes, 2015
These three editions of the same brochure were written and distributed by the Appalachian National Park Association. The booklets list multiple reasons to support the “establishment of a national park in the mountains of western North Carolina.” Printed ...
Appalachian National Park Association;
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

The natural landscape of urban everyday life in the perception of the population (by the example of Penza in the 19th – 20th centuries)

open access: yesИзвестия высших учебных заведений. Поволжский регион: Гуманитарные науки
Background. The evolution of the urban landscape and the interaction of citizens with it is an integral part of the appearance of the city, which is reflected in the historical memory of the population.
A.A. Gushchin
doaj   +1 more source

Appalachian National Park Association Newspaper Clippings, 1902-1907, 1925, 1928

open access: yes, 2015
This is one of two notebooks assembled by the Appalachian National Park Association that includes documents and news clipping about the organization. The Appalachian National Park Association was formed in 1899 for the purpose of promoting the idea of a ...
Appalachian National Park Association;
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

View of Park City ski runs.

open access: yes, 1994
A view of Park City ski runs, photo taken between 1994 and ...
Park City Ski Corp. / Lori Adamski Peek
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Skier floating on powder at Park City.

open access: yes, 1995
Photograph of an unidentified skier at the Park City ski resort, taken between 1995 and ...
Park City Ski Corp. / Lori Adamski Peek
core  

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