Results 121 to 130 of about 2,049,123 (312)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Editorials commenting on the Appalachian National Park movement

open access: yes, 2015
This undated, typewritten 20-page document lists various favorable comments made about the Appalachian National Park Association by newspapers and individuals from all over the country.
Ambler, Chase P., 1865-1932;
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Memorandum to Appalachian National Park Association membership

open access: yes, 2015
This 3-page memorandum was written in September 1901 by Appalachian National Park Association president George S. Powell (b. 1848). Powell includes a summary of the association’s accomplishments to date as well as a quote by Senator Pritchard advocating ...
Powell, George S.;
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Chabe National Park Tourist Map

open access: yes, 1977
Botswana Map- TouristA tourist map of Botswana's Chabe National ...
Chabe National park
core   +1 more source

Stickers: Push the Appalachian National Park

open access: yes, 2015
The Appalachian National Park Association carried out a wide-ranging promotional campaign throughout the eastern U.S. Within the first few months of its operation, the Association printed these colorful stickers with the motto, “Push the Appalachian ...
Appalachian National Park Association;
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Willamalane Park & Recreation District : Lively Park master plan

open access: yes, 2005
38 pp. Includes maps. Adopted September 28, 2005. Captured March 20, 2007.The Lively Park Master Plan identifies and documents the long-term, desired development of Jack B. Lively Memorial Park (Lively Park), home of Splash!
Willamalane Park and Recreation District
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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