Results 291 to 300 of about 9,561,546 (382)

A sex- and gender-informed future for Parkinson's disease care. [PDF]

Clin Transl Med
Barbato M, Guzman B, Dixit S, Chadha AS, Marongiu R.   +4 more
europepmc   +1 more source

ATP Hydrolysis by α‐Synuclein Amyloids is Mediated by Enclosing β‐Strand

Advanced Science, EarlyView.
Pathological amyloids have been considered chemically inert until recently. Here it is shown that α‐synuclein amyloids catalyze the hydrolysis of the universal energy molecule, ATP. The cryo‐EM structure of the complex reveals an additional β‐strand (purple) that encloses the ATP‐binding site. Within the cavity, several lysine residues are required for
Lukas Frey, Fiamma Ayelen Buratti, Istvan Horvath, Shraddha Parate, Ranjeet Kumar, Roland Riek, Pernilla Wittung‐Stafshede   +6 more
wiley   +1 more source

The Incidence of Benzodiazepine and Benzodiazepine-Related Drug Use in People With and Without Parkinson's Disease-A Nationwide Cohort Study. [PDF]

Basic Clin Pharmacol Toxicol
Lonka V, Hartikainen S, Tiihonen M, Koponen M, Tolppanen AM.   +4 more
europepmc   +1 more source

Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization

Advanced Science, EarlyView.
Molecular glues that stabilize protein–protein interactions are challenging to identify. Here, hydrogen‐deuterium exchange mass spectrometry can show and reveal gluing mechanisms that vary between protein binding partners. Abstract Molecular glues are powerful bioactive molecules that stabilize protein–protein interactions.
Danielle F. Kay, Hadeeqa G. Raza, Richard G. Doveston, Aneika C. Leney   +3 more
wiley   +1 more source

Functional and Structural Characterization of LRRK2 p.V1447L in Parkinson's Disease. [PDF]

Mov Disord
Pratuseviciute N, Lis P, Weber S, Gruchy N, Arnaud L, Alessi DR, Sammler E.   +6 more
europepmc   +1 more source

Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease.

New England Journal of Medicine, 2010
K. Follett, F. Weaver, M. Stern, K. Hur, C. Harris, Ping Luo, W. Marks, J. Rothlind, O. Sagher, C. Moy, R. Pahwa, K. Burchiel, P. Hogarth, E. Lai, J. Duda, K. Holloway, A. Samii, S. Horn, J. Bronstein, Gatana Stoner, P. Starr, R. Simpson, G. Baltuch, A. D. De Salles, Grant D. Huang, D. Reda   +25 more
semanticscholar   +1 more source

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

Correction: Peripheral cutaneous synucleinopathy characteristics in genetic Parkinson's disease. [PDF]

Front Neurol
Yuan Y, Wang Y, Liu M, Luo H, Liu X, Li L, Mao C, Yang T, Li S, Zhang X, Gao Y, Xu Y, Yang J.   +12 more
europepmc   +1 more source

Procyanidin B3 and Its Derivatives Alleviate Neuronal Injury by Targeting G3BP1 for Ischemic Stroke Therapy

Advanced Science, EarlyView.
Ischemic stroke is a serious disease with high rates of mortality and disability, but there is a lack of novel therapeutic targets and agents for it. Now it is shown that Ras GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1) has the potential to serve as a therapeutic target for ischemic stroke.
Heyanhao Zhang, Yuyu Zhang, Yibo Chen, Wen Zhong, Subei Tan, Jinghuan Wang, Huanren Yan, Ning Yan, Mengjia Lin, Xinhua Liu, Jun Chang   +10 more
wiley   +1 more source

Investigational Gene Therapies for Parkinson's Disease. [PDF]

CNS Drugs
Phielipp N, Henchcliffe C.
europepmc   +1 more source