Results 301 to 310 of about 9,561,546 (382)

Dual Hydrophilic‐Hydrophobic Core Architecture in Soy Glycinin Amyloid Fibrils Revealed by Cryo‐EM

Advanced Science, EarlyView.
While high‐resolution structures of animal and microbial amyloids are extensively characterized, the structural principles underlying plant‐derived amyloids remain largely unexplored. The study addresses this fundamental gap in knowledge by determining the first near‐atomic‐resolution cryo‐EM structures of amyloid fibrils derived from soy glycinin ...
Saiya Li, Shuangjian Li, Yijia Cheng, Yapeng Fang, Qin Cao, Yiping Cao   +5 more
wiley   +1 more source

A Perspective on Improving Quality of Life of Parkinson's Disease Patients in Rural Nepal: Filling the Gaps. [PDF]

Health Sci Rep
Upadhyay D, Ojha R.
europepmc   +1 more source

MPTP: an industrial chemical and contaminant of illicit narcotics stimulates a new era in research on Parkinson's disease.

, 1987
Irwin J. Kopin
openalex   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

Coffee Consumption Is Associated With Later Age-at-Onset of Parkinson's Disease. [PDF]

Ann Clin Transl Neurol
Kuzovenkova D, Liu L, Gan-Or Z, Senkevich K.   +3 more
europepmc   +1 more source

Computational Fluid Dynamic Model Prediction of Enhanced Glymphatic Clearance in Response to Focused Ultrasound‐Mediated Blood‐Brain Barrier Opening

Advanced Science, EarlyView.
Focused ultrasound‐mediated blood‐brain barrier opening (FUS BBBO) for enhanced drug delivery also augments glymphatic clearance. A computational model of an arteriole‐venule pair in the brain offers insight into the underlying biotransport mechanisms responsible for this mass clearance effect.
Ryan A. Gladwell, Delaney G. Fisher, Joshua D. Wythe, Christopher B. Highley, John R. Lukens, Richard J. Price   +5 more
wiley   +1 more source

Proceedings of the world summit on parkinson's disease. [PDF]

NPJ Parkinsons Dis
Mantri S, Ghilardi MF, Lessard N, Norcini M, Di Rocco A, Wallock K, Lehr J, Okun MS, World Summit Steering Committee.   +8 more
europepmc   +1 more source

Disability profiles and objective quantitative assessment in Parkinson's disease

, 1989
Bo Johnels, Páll Ingvarsson, M. Thorselius, Marjorie Valls, G. Steg   +4 more
openalex   +1 more source

Spatially Resolved Mapping of Voltage‐Gated Proton Channel Activity Reveals Delayed Proton Transport in Local Microenvironments

Advanced Science, EarlyView.
A revolutionary imaging platform integrating quantitative single‐molecule photobleaching with ratiometric fluorescence probes enables high‐throughput (≈2300 individually resolvable channels) mapping of individual proton channels in a large field (≈3000 µm2), overcoming the spatial and temporal limitations of conventional electrophysiology.
Jiahua Zhuang, Yang Xu, Yuxian Lu, Shiyang Lyu, Jie Tan, Jiandong Feng   +5 more
wiley   +1 more source

Circulating particles carotenoids are associated with rehabilitation recovery in Parkinson's disease. [PDF]

Redox Biol
Gualerzi A, Gerli M, Mangolini A, Picciolini S, Rodà F, Mangolini V, Doronzio S, Longo D, Cherubini G, Polito C, De Santis C, Ramat S, Cecchi F, Lombardi G, Bedoni M.   +14 more
europepmc   +1 more source