Results 261 to 270 of about 236,137 (343)

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Contralateral spread of unilateral tremor in Parkinson’s Disease

Pasquini J, Pavese N, Ceravolo R, Helmich RC, Deuschl G.   +4 more
europepmc   +1 more source

Validating the Accuracy of Parkinson's Disease Clinical Diagnosis: A UK Brain Bank Case–Control Study

Annals of Neurology, EarlyView.
Objective Despite diagnostic criteria refinements, Parkinson's disease (PD) clinical diagnosis still suffers from a not satisfying accuracy, with the post‐mortem examination as the gold standard for diagnosis. Seminal clinicopathological series highlighted that a relevant number of patients alive‐diagnosed with idiopathic PD have an alternative post ...
Lazzaro di Biase, Pasquale Maria Pecoraro, Vincenzo Di Lazzaro   +2 more
wiley   +1 more source

Frequency and Early Predictors of Cognitive Deterioration in Amyotrophic Lateral Sclerosis: A Longitudinal Population‐Based Study

Annals of Neurology, EarlyView.
Objective The objective is to evaluate cognitive and behavioral progression and identify early predictors of these changes in a cohort of amyotrophic lateral sclerosis (ALS) patients. Methods A total of 161 ALS patients were tested at diagnosis (T0), and 107 were re‐tested after 1 year (T1) using cognitive/behavioral tests. All patients underwent whole‐
Barbara Iazzolino, Francesca Palumbo, Cristina Moglia, Umberto Manera, Maurizio Grassano, Enrico Matteoni, Sara Cabras, Maura Brunetti, Rosario Vasta, Marco Pagani, Gabriele Mora, Antonio Canosa, Andrea Calvo, Adriano Chiò   +13 more
wiley   +1 more source

The Exon-Based Transcriptomic Analysis of Parkinson's Disease. [PDF]

Biomolecules
Kõks S.
europepmc   +1 more source

Cyclic Alternating Pattern Dynamics in Individuals at Risk for Developing Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The objective of this study was to investigate the differences in cyclic alternating patterns (CAP) metrics, a non‐rapid eye movement (NREM) sleep physiological rhythm, among recently diagnosed patients with Parkinson's disease (PD), and individuals at high and low risk for developing PD based on genetic and prodromal risk.
Andrew Dagay, Shlomit Katzav, Danielle Wasserman, Valentina Gnoni, Anat Mirelman, Riva Tauman   +5 more
wiley   +1 more source

Polygenic scores for disease risk are not associated with clinical outcomes in Parkinson’s disease

Tan MM, Iwaki H, Bandres-Ciga S, Sosero Y, Shoai M, Brockmann K, Williams NM, Alcalay RN, Maple-Grødem J, Alves G, Tysnes O, Auinger P, Eberly S, Heutink P, Simon DK, Kieburtz K, Hardy J, Williams-Gray CH, Grosset DG, Corvol J, Gan-Or Z, Toft M, Pihlstrøm L.   +22 more
europepmc   +1 more source

Blood DDIT4 and TRIM13 Transcript Levels Mark the Early Stages of Machado–Joseph Disease

Annals of Neurology, EarlyView.
Objective An abundance of select transcripts and proteins has been found to be dysregulated in blood samples of Machado–Joseph disease (MJD) carriers. Here, we aimed to: (1) identify blood transcriptional changes as potential biomarkers of MJD; (2) correlate levels of differentially expressed blood transcripts with MJD carriers features; and (3 ...
Ana F. Ferreira, Mafalda Raposo, Emily D. Shaw, Louisa Liu, João Vasconcelos, Teresa Kay, Conceição Bettencourt, Maria Luiza Saraiva‐Pereira, Laura Bannach Jardim, Maria do Carmo Costa, Manuela Lima   +10 more
wiley   +1 more source

LIBX‐A401: A Novel Selective Inhibitor of Acyl‐CoA Synthetase Long Chain Family Member 4 (ACSL4) and Its Binding Mode

Angewandte Chemie, EarlyView.
The discovery of LIBX‐A401, a potent and selective ACSL4 inhibitor derived from rosiglitazone is reported. HDX‐MS reveals that LIBX‐A401 stabilizes the ACSL4 C‐terminus and alters the fatty acid (FA) gate domain. Consistently, photoaffinity labeling, molecular dynamics, and mutagenesis identify key binding residues within the FA pocket.
Darius Mazhari Dorooee, Séverine Ravez, Didier Vertommen, Nicolas Renault, Nicolas Papadopoulos, Romain Marteau, Emeline Charnelle, Karine Porte, Alexandre Gobert, Nathalie Hennuyer, Gaetan Herinckx, Maëla Pautric, Aurélie Jonneaux, Jean Christophe Devedjian, David Devos, Bart Staels, Patricia Melnyk, Stefan N. Constantinescu, Raphaël Frédérick, Jamal El Bakali   +19 more
wiley   +2 more sources

Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective Although dopamine transporter (DaT) imaging is a valuable diagnostic biomarker, few studies have investigated its utility in objectively monitoring disease progression in patients with Parkinson's disease (PD). To date, no study has established a longitudinal relationship between the DaT signal decline and the motor symptom increase ...
Verena Dzialas, Gérard N. Bischof, Kathrin Möllenhoff, Alexander Drzezga, Thilo van Eimeren   +4 more
wiley   +1 more source