Results 241 to 250 of about 9,643,208 (350)

A Closed‐Loop‐Capable Neural Interface Platform for Deep Brain Modulation via Integrated Non‐Viral Gene Delivery, NIR Optogenetics, and Electrophysiological Recording

Advanced Science, EarlyView.
A multifunctional, 3D porous neural interface combines non‐viral gene delivery and NIR optogenetics to enable minimally invasive, closed‐loop modulation of deep‐brain circuits. Abstract Closed‐loop neuromodulation requires precise, stable, and cell‐specific control of neural circuits with minimal invasiveness.
Chao‐Yi Chu, Zih‐Huei Chen, Chun‐Wei Liang, Pu‐Wei Wu, Wei‐Qing Guo, Bo‐Wei Chen, Chih‐Chia Huang, Ssu‐Ju Li, Ching‐Wen Chang, Yao‐Wen Liang, Shun‐An Kan, Yu‐Chun Lo, Wei‐Chen Huang, You‐Yin Chen, San‐Yuan Chen   +14 more
wiley   +1 more source

Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein [PDF]

, 2014
Misook Oh, Ji Hoon Lee, Wei Wang, Hui Sun Lee, Woo Sirl Lee, Christopher Burlak, Wonpil Im, Quyen Q. Hoang, Hyun‐Suk Lim   +8 more
openalex   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Association Between Turn Impairments and Cognitive Function in Parkinson Disease. [PDF]

Aging Med (Milton)
Xu S, Kong L, Liu X, Lou Y, Gu L, Xu Q, Tan X, Pu J, Zhang B.   +8 more
europepmc   +1 more source

Comparison of strength training, aerobic training, and additional physical therapy as supplementary treatments for Parkinson’s disease: pilot study

, 2015
A Carvalho, D Barbirato, Nathasia Christyelle Rolim de Araújo, Martins JV, Sá Cavalcanti JL, Santos TM, Coutinho ES, J Laks, Deslandes AC   +8 more
openalex   +1 more source

Validity of International Classification of Functioning, Disability, and Health Core Set in Patients with Parkinson's Disease and the Correlation with other Parkinson Scales

, 2020
İbrahim Acır, Hacı Ali Erdoğan, Vildan Yayla   +2 more
openalex   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Differentiating effects of levodopa and subthalamic nucleus deep brain stimulation on motor features in Parkinson disease. [PDF]

Clin Park Relat Disord
Lee TA, Ramesh D, Ushe M, Norris SA, Tabbal SD, Perlmutter JS, Younce JR.   +6 more
europepmc   +1 more source

Five times sit-to-stand test performance in Parkinson\u27s disease [PDF]

, 2011
Duncan, Ryan P, Earhart, Gammon M, Leddy, Abigail L   +2 more
core   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source