Results 321 to 330 of about 435,882 (385)

Self‐Administered Taste Testing Without Water: Normative Data for the 53‐Item Waterless Empirical Taste Test (WETT)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background According to the National Health and Nutrition Examination Survey (NHANES), more than 20 million Americans suffer from chronic taste problems. Unfortunately, quantitative testing is rarely performed, self‐reports are inaccurate, and “taste” is often confused with olfaction‐dependent flavors.
Richard L. Doty, Ryan Sharetts, Shima T. Moein   +2 more
wiley   +1 more source

A common outcome set for trials in dementia with Lewy bodies (DLB COS). [PDF]

Alzheimers Dement (N Y)
Kane JPM, Fitzpatrick RL, Betzhold S, Daly G, Kalfas E, Kinchin I, Aarsland D, Greaney K, Grycuk E, Folkerts AK, Kalbe E, Rodriguez-Porcel F, Saldanha IJ, Smith V, Taylor JP, Thompson R, Wyman-Chick K, Leroi I, and The DLB COS Delphi Group.   +18 more
europepmc   +1 more source

Olfactory Impairment and Incident Cognitive Decline: A Systematic Review and Meta‐Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory impairment (OI) is associated with poor ageing outcomes. While cross‐sectional studies found a high prevalence of OI among patients with neurodegenerative diseases, the temporal relationship remains unclear. This meta‐analysis aims to synthesise the longitudinal association of OI with cognitive decline (CD). Methods PubMed,
Brian Sheng Yep Yeo, Harris Jun Jie Muhammad Danial Song, Benjamin Kye Jyn Tan, Adithya Suresh, Owen Tsung Wen Ho, Jun He Chan, Esther Yanxin Gao, Claire Jing‐Wen Tan, Chong Boon Teo, Christopher Li‐Hsian Chen, Laura Tay, Ecosse L. Lamoureux, Thomas Hummel, Anna See, Shuhui Xu, Song Tar Toh, Tze Choong Charn, Neville Wei Yang Teo   +17 more
wiley   +1 more source

Glutathione Decreases Parkinsonism-Induced Ferroptosis and Oxidative Stress Through the Inhibition of the TRPM2 Channel in Neuronal Cells. [PDF]

Pharmacol Res Perspect
Güzel E, Sayın Şakul AA, Nazıroğlu M.   +2 more
europepmc   +1 more source

Cistanche tubulosa improves peripheral neuropathy in MPTP‐induced PD mice based on regulation of m6A methylation

Animal Models and Experimental Medicine, EarlyView.
At steady state, DRG ensures low‐level expression of TH+ neurons under the protection of AKT. However, the DRG level of PD mouse model under MPTP toxicity increased significantly, and the expression of IL‐6 and CASP3 increased. This process was accompanied by the occurrence of m6A demethylation, with a significant increase in FTO as the main ...
Yatan Li, Wei Jia, Junhua Hu, Borui Zhang, Xinxin Qi, Jianhua Yang, Xinling Yang   +6 more
wiley   +1 more source

Two-step detection of Lewy body pathology via smell-function testing and CSF α-synuclein seed amplification. [PDF]

Nat Commun
Mastenbroek SE, Collij LE, Vogel JW, Caldera S, Serrano GE, Adler CH, Vargiu CM, Palmqvist S, Barkhof F, Parchi P, Beach TG, Ossenkoppele R, Hansson O.   +12 more
europepmc   +1 more source

Establishment of a humanized SCA2 mouse model carrying a CAA disruption preventing CAG repeat expansion in pathogenic genes

Animal Models and Experimental Medicine, EarlyView.
In this study, we established a mouse model in which CAG repeats do not undergo microsatellite instability (MSI) across generations. A humanized ATXN2 cDNA with four CAA interruptions within 73 CAG expansions was inserted into the Rosa26 locus of C57BL/6J mice. At the same time, a 23 CAG control mouse model was also generated.
Yao Zhang, Yufei Li, Lin Zhang, Zhaoqing Li, Keqin Lin, Kai Huang, Zhaoqing Yang, Shaohui Ma, Hao Sun, Xiaochao Zhang   +9 more
wiley   +1 more source

[¹⁸F]Florzolotau PET for the Differential Diagnosis of Parkinsonism in Patients with Suspected 4-Repeat Tauopathies. [PDF]

J Nucl Med
Brumberg J, Schröter N, Blazhenets G, Omrane MA, Volz C, Weiller C, Rijntjes M, Frings L, Hellwig S, Jost WH, Meyer PT.   +10 more
europepmc   +1 more source

Parkinsonism, Psychomotor Slowing, Negative and Depressive Symptoms in Schizophrenia Spectrum and Mood Disorders: Exploring Their Intricate Nexus Using a Network Analytic Approach. [PDF]

Schizophr Bull
Fritze S, Brandt GA, Benedyk A, Moldavski A, Volkmer S, Daub J, Krayem M, Kukovic J, Schwarz E, Braun U, Wolf RC, Kubera KM, Northoff G, Meyer-Lindenberg A, Tost H, Hirjak D.   +15 more
europepmc   +1 more source