Results 141 to 150 of about 963,803 (317)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

About Liberal Professions in Romania: Dysfunctions and Disturbances.

open access: yesManagement Dynamics in the Knowledge Economy, 2013
This paper presents the main aspects of the liberal professions in Romania from the legislative point of view. It is a comparative analysis based on European and Romanian legislation.
Ioan GHIȘE
doaj  

Exhibitions in a Political Context and Their Impact on Knowledge Democracy

open access: yesSocial Sciences
Parliaments play a key role in the concept of knowledge democracy. They contribute to the production and dissemination of knowledge, promote critical thinking and opinion formation, and strengthen democracy through high-quality laws.
Matthias Keppel
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Exploring the People’s Housing Process: An application of the 1986 Rhodes Policy Network model

open access: yesActa Structilia, 2011
A formal policy supporting the People’s Housing Process (PHP) was released in 1998. This policy and subsequent support measures in many ways mandates a policy implementation network.
Anneke Clark
doaj  

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

open access: yesFEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama   +7 more
wiley   +1 more source

THE SESSION IN PARLIAMENT OF GREAT BRITAIN ABOUT LEAVING ISTANBUL TO THE OTTOMAN ADMINISTRATION

open access: gold, 2020
Çağdaş Yüksel   +9 more
openalex   +1 more source

Choosing the electoral system: why not simply the best one? [PDF]

open access: yes
The paper illustrates a simple empirical rule to choose the best electoral system for a Parliament.
Ortona, Guido
core  

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