Results 71 to 80 of about 197,825 (332)

The concept of Index for the Assessment of Regulations' Significance (IARS) in regulatory impact evaluation [PDF]

, 2019
This article aims to present the concept of the Index for the Assessment of Regulations’ Significance as a tool used in parliamentary regulatory impact assessment, with a special focus on expost assessment.
Marchewka-Bartkowiak, Kamilla
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Legitimacy and the cognitive sources of international institutional change: The case of regional parliamentarization [PDF]

, 2019
How and under what conditions does legitimacy affect processes of international institutional change? This article specifies and evaluates three causal mechanisms by which variation in legitimacy induces institutional change in international ...
Burilkov, Alexandr, Lenz, Tobias, Viola, Lora Anne   +2 more
core   +2 more sources

National parliaments fighting back? Institutional engineering as a successful means to become active actors in EU affairs

Perspectives on Federalism, 2016
The European integration process has long been characterised by the predominance of national executive powers. National parliaments were recognised as European actors after several decades only, in the Maastricht Treaty first and to an even larger extent
Fromage Diane
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Parliament as a Workplace: Dilemmas of Vernacularisation and Professionalisation

Politics and Governance
In this article, we engage with recent calls to research parliaments as gendered workplaces, which build on earlier international discursive turn and institutional reform initiatives towards gender-sensitive parliaments.
Mouli Banerjee, Shirin M. Rai
doaj   +1 more source

Too late to dissolve the people and elect another? Cognition, Contingent Consent and Turbulence in the Integration Process? [PDF]

, 2009
Consent to the process of European integration is contingent and the reproduction of consent is, in Renan’s (1882) terms, a ‘daily plebiscite’. Each new Treaty conveys a new understanding of what the EU is and ought to be.
Cram, Laura
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Role Conceptualisations and the Purple Zone: Parliamentary Staff Through the Eyes of Former MPs

Politics and Governance
We analyse how former MPs describe and assess the various staff groups when talking about the daily work of the Finnish parliament. Our theoretical framework draws on the politics/administration divide and the concept of a “purple zone” blending the ...
Kanerva Kuokkanen, Marjukka Weide
doaj   +1 more source