Results 111 to 120 of about 17,671 (283)

The two-step scenario of the Messinian Crisis (Clauzon et al., 1996): a specification supported by new data

open access: yesBSGF - Earth Sciences Bulletin
Many papers refer in a revised way to the two-step scenario of the Messinian Crisis conceived by Clauzon et al. (1996). The present paper recalls the basis for the two-step scenario and discrepancies with the later modified version, completed by new data
Suc Jean-Pierre   +21 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Automatic Mode Switching in Atrial Fibrillation [PDF]

open access: yes, 2005
Automatic mode switching (AMS) algorithms were designed to prevent tracking of atrial tachyarrhythmias (ATA) or other rapidly occurring signals sensed by atrial channels, thereby reducing the adverse hemodynamic and symptomatic consequences of a rapid ...
Antonio De, Simone   +2 more
core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Paroxysmal supraventricular tachycardias: modern principles of diagnostics and treatment

open access: yesКардиоваскулярная терапия и профилактика, 2005
The article is devoted to one of the most actual problems in modern arrhythmology - treatment of paroxysmal supraventricular tachycardias. Modern views on diagnostics and treatment of atrio-ventricular (AV) nodal reciprocating tachycardia and AV ...
A. V. Vetluzhsky, I. G. Fomina
doaj  

Суб’єктивне та об’єктивне В лексико-семантичній структурі слова "storm": на матеріалі англомовних словників [PDF]

open access: yes, 2010
Стаття є спробою аналізу лексико-семантичної структури слова "storm" на матеріалі англомовних словників. Велика увага приділяється дослідженню форм лексикографічного відображення суб’єктивності та об’єктивності у структурі лексеми "storm"; розглядається ...
Пилячик, Н. Є.
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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