Results 21 to 30 of about 86,213 (145)

One haemolytic anaemia may hide another: Paroxysmal nocturnal haemoglobinuria masquerading as Plasmodium falciparum infection [PDF]

European Journal of Case Reports in Internal Medicine
Background: Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, genetic and acquired haematologic disease that causes complement-mediated intravascular haemolytic anaemia, thrombosis and bone marrow failure.
Alexandre-Raphael Wery, Coline Mortier, Quentin Cabrera, Mohamadou Niang, Moumini Kone, Sarah Permal   +5 more
doaj   +2 more sources

Thrombosis and paroxysmal nocturnal haemoglobinuria

Thrombosis Update, 2021
Thrombosis is the most common, most feared complication of paroxysmal nocturnal haemoglobinuria (PNH), a striking example of the effect of uncontrolled complement activation and haemolysis on vascular biology and haemostasis.
Jean-Christophe Gris, Mathias Chéa, Florence Guillotin, Mathieu Fortier, Chloé Bourguignon, Éric Mercier, Sylvie Bouvier   +6 more
doaj   +1 more source

Coronary Artery By-Pass Grafting in Patient With Paroxysmal Nocturnal Hemoglobinuria (Case Report)

Общая реаниматология, 2021
Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell disease that presents with haemolytic anaemia, thrombosis and bone marrow failure.
A. Amendola, G. Paternoster, S. P Pascale, R. Nuccorini, M. D'Amora, G. Pittella, R. D'Ascoli, F. Prestipino, G. Luzi, M. Pizzuti   +9 more
doaj   +1 more source

Recurrent venous thrombosis – an unusual first presentation of autoimmune polyendocrinopathy syndrome type 3B

South African Medical Journal, 2023
A 45-year-old female presented with unprovoked recurrent venous thromboembolism (VTE), in unusual sites, and pancytopenia, posing a complex diagnostic challenge.
N Letete, D Vaz, P H Malishi, J J Pogieter, P Rheeder   +4 more
doaj   +1 more source

Paroxysmal Nocturnal Haemoglobinuria Masquerading as Malaria: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2015
Paroxysmal Nocturnal Haemoglobinuria (PNH) is a rare type of acquired Haemolytic anaemia that is described as a triad of acquired intravascular Haemolysis, venous thrombosis and anaemia with pancytopenia sometimes due to bone marrow failure. However the
Archana Dambal, Naren V Nimbal, Shanmukh T Kalsad, K Pramod, M P Madhavaranga   +4 more
doaj   +1 more source

Classic paroxysmal nocturnal haemoglobinuria presenting with intestinal malabsorption syndrome, acute abdomen and acute kidney injury. [PDF]

BMJ Case Rep
A male patient in his 30s presented with complaints of acute abdominal pain, black stools and red-coloured urine. CT revealed thrombi in the splenic and left renal veins, leading to infarctions.
Porel R, Kumar A, Ajit S, Ojha VS, Biswas R.   +4 more
europepmc   +2 more sources

A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria [PDF]

, 2004
Background<br/><br/> Mutations in the gene coding for the RNA component of telomerase, hTERC, have been found in autosomal dominant dyskeratosis congenita (DC) and aplastic anemia.
Ulku, B., Bessler, M., Bilsland, A., Mason, Philip J, Vulliamy, T., Serakinci, Nedime, Dokal, I., Ar, C., Ar, C, Marrone, Anna, Dokal, Inderjeet, Ulku, B, Bessler, Monica, Erzik, C, Serakinci, N, Serakinci, N., Marrone, A, Zhao, Jiangqin, Zhao, J, Dokal, I, Bilsland, A, Mason, PJ, Bilsland, Alan, Ulku, Birsen, Keith, W.N., Bessler, M, Vulliamy, T, Vulliamy, Tom, Keith, W Nicol, Erzik, Can, Marrone, A., Erzik, C., Zhao, J., Mason, P.J., Ar, Cem, Keith, WN, Tom Vulliamy, Alan Bilsland, W Nicol Keith, Jiangqin Zhao, Monica Bessler, Anna Marrone, Inderjeet Dokal, Nedime Serakinci, Philip J Mason, Cem Ar, Can Erzik, Birsen Ulku   +47 more
core   +2 more sources

The burden of illness of patients with paroxysmal nocturnal haemoglobinuria receiving C5 inhibitors: clinical outcomes and medical encounters from the patient perspective

Hematology, 2022
Objectives: To assess the clinical and healthcare resource burden among C5 inhibitor (C5i)-treated patients with paroxysmal nocturnal haemoglobinuria (PNH), using patient-reported data.Methods: This web-based, cross-sectional survey (01FEB2021–31MAR2021)
Flore Sicre de Fontbrune, Pascale Burmester, Maria Piggin, Joana E. Matos, Halley Costantino, Koo Wilson, Zalmai Hakimi, Jameel Nazir, Renaud Desgraz, Jesse Fishman, Emmelie Persson, Jens Panse   +11 more
doaj   +1 more source

Pharmacological Therapies in Paroxysmal Nocturnal Haemoglobinuria: Focus on Complement Inhibition. [PDF]

Drugs
Paroxysmal nocturnal haemoglobinuria (PNH) is an ultra-rare acquired genetic stem cell disorder based on a mutation in the PIGA gene that results in susceptibility of resulting blood cells to complement-mediated intravascular haemolysis (IVH).
Kelly RJ, Holt M, Szer J.
europepmc   +2 more sources

Pulmonary embolism in a patient with eltrombopag-treated aplastic anaemia and paroxysmal nocturnal haemoglobinuria clone during COVID-19 pneumonia

Thrombosis Journal, 2022
Thrombosis in patients with thrombocytopenia has several risk factors, both disease-related and treatment-associated. Recently, COVID-19 infection was recognized as an additional risk factor, further complicating the delicate balance between thrombosis ...
Bosi Alessandro, Barcellini Wilma, Fattizzo Bruno   +2 more
doaj   +1 more source