Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria
British Journal of Clinical Pharmacology, EarlyView.Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin +6 more
wiley +1 more source
Evolution of the Metazoan Protein Domain Repertoire Revealed by a Birth-Death-Gain Model. [PDF]
J Mol EvolXiao Y +3 more
europepmc +1 more source
Real‐Time Biomass Estimation in High‐Density Yeast Fermentations Using Soft Sensor Modeling
Biotechnology and Bioengineering, EarlyView.Accurate biomass measurements, both offline and online, are essential to improve prediction and control in yeast fermentation. This study develops regression‐based predictive models to correlate offline measurements (Dry Cell Weight and OD600 from a spectrophotometer) with online OD860 probe signals to provide accurate real‐time biomass estimations and
Ana G. Del Hierro +3 more
wiley +1 more source
Clinic-first sepsis recognition in the ICU: a proteomics-guided, parsimonious model with independent validation. [PDF]
Clin ProteomicsArdabili AK +4 more
europepmc +1 more source
Automated Data‐Efficient Symbolic Regression for Interpretable Bioprocess Model Development
Biotechnology and Bioengineering, EarlyView.ABSTRACT Bioprocessing is central to the sustainable manufacture of pharmaceuticals, food products, and renewable chemicals. Consequently, developing high‐fidelity kinetic models to facilitate accurate process prediction, optimisation, and scale‐up is a top research priority.
Luca Riezzo +3 more
wiley +1 more source
The osteology, taxonomy, and phylogenetic affinities of the Early Jurassic plesiosaur <i>Lusonectes sauvagei</i>. [PDF]
PeerJSachs S, Madzia D.
europepmc +1 more source
Loss, persistence and reversal of phenotypic traits
Biological Reviews, EarlyView.ABSTRACT The irreversibility of complex trait loss has long been a tenet of evolutionary biology. However, this idea is increasingly at odds with the numerous documented exceptions across the Tree of Life. We synthesise this growing body of evidence across a diverse array of taxa and traits, exploring the evolutionary conditions that enable ...
Giobbe Forni +4 more
wiley +1 more source
Biological Reviews, EarlyView.ABSTRACT Recent methodological development in phylogenetic inference has focused predominantly on molecular data. However, renewed interest in other data types, particularly morphological data, has followed from the increased recognition of the power of total evidence and tip‐dating approaches, including fossil data, for inference of time‐scaled trees ...
Melanie J. Hopkins +9 more
wiley +1 more source
Three new species of <i>Dacryobolus</i> (<i>Polyporales</i>, <i>Basidiomycota</i>) from southern China. [PDF]
MycoKeysZhu QZ, Ye J, Huang MR, He SH, Yuan Y.
europepmc +1 more source
Utterance evolution: the road to generative, combinatorial communicators
Biological Reviews, EarlyView.ABSTRACT Language has long been considered uniquely complex in the animal kingdom; however, animal research over the last decade has begun to challenge some long‐standing premises about exactly which language capacities are uniquely human. The task of resolving why and how complex communication systems evolve, particularly human language, has ...
Catherine Crockford +2 more
wiley +1 more source