Results 81 to 90 of about 3,582,018 (301)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Existence dependency: conceptual modelling by contract. [PDF]
In Object Orientation, the Generalisation/Specialisation hierarchy and the Whole/Part relationship are prevalent classification schemes for object types.
Dedene, Guido, Snoeck, Monique
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Indian Journal of Endocrinology and Metabolism, 2012 Introduction: Hypothyroidism is a known consequence of external-beam radiotherapy to the neck encompassing a part or whole of the thyroid gland. In this non-randomized prospective study, we have tried to evaluate the response of the thyroid gland to ...
B A Laway +6 more
doaj +1 more source
Annali di Ca’ Foscari: Serie Orientale, 2020 The neurological bimodality theory, espousing the principles of directionality and cerebral hemisphericity, has led to a series of expedients in the field of foreign language teaching, like the use of inductive strategies.
Facchin, Andrea
doaj +1 more source
Electrofishing survey of the River Calder and its tributaries - April 1978. [PDF]
, 1978 An electrofishing survey was undertaken in the period April 24th - 28th as part of the detailed biological study of the Calder Catchment being carried out by this department in early 1978.
Williams, B.
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The Epistle to the Galatians and Classic Rhetoric: Parts 1 & 2
Tyndale Bulletin, 1994 Is it a useful or valid approach to St. Paul’s Epistles to analyse them in terms derived from the classical Greek and Roman rhetorical theorists? In the following three-part exploration of this question, of which the first two parts appear here and the ...
Janet Fairweather
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Montesquieu.it, 2016 This article regards the relation between the principle of Monarchy, the Honor (The Spirit of Laws, III, 7) and the project of Traité des devoirs. In the first part of this paper, I will consider some Works – in particular the Discours sur Cicéron and ...
Federico Bonzi
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source