Results 141 to 150 of about 6,486,063 (267)

Composting Dynamics, Bedding Properties, and Seasonal Effects in Composting and Non-Composting Bedded-Pack Barns in a Subtropical Region. [PDF]

Animals (Basel)
Danieli B, de Vitt MG, Bertipaglia FJG, Domingues JV, Zampar A, Zotti MLAN, Ferraz PFP, Schogor ALB.   +7 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

P639: Excavator: Removing the noise in exome analysis using machine learning

Genetics in Medicine Open
Brett Deml, Lexie Lobo, Becky Milewski, Benjamin Bluhm, Luke Drury   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Front Matter Volume 16.2

Scottish Studies, 1972
[Editor]
doaj  

Changes in Medication Use After Medicare Part D Annual Out-of-Pocket Spending Caps.

JAMA Health Forum
Cai CL, Anderson KE, Kesselheim AS, Rome BN.   +3 more
europepmc   +1 more source

Randomized, Placebo-Controlled, First-in-Human Study of the Safety, Tolerability, and Pharmacokinetics of Single and Repeat Oral Doses of Novel Antitubercular Drug Candidate, GSK2556286, in Healthy Adults. [PDF]

J Clin Pharmacol
Ilsley E, Banham-Hall E, Chaychenko T, Chinenyeze K, Maher-Edwards G, Muya C, Rolfe K, Sharma R, Tiberi S, Barros-Aguirre D.   +9 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Front Matter Volume 15.1

Scottish Studies, 1971
[Editor]
doaj  

Clinical CYP2D6-Mediated Pharmacokinetic Drug-Drug Interactions of DA-8010 with Paroxetine or Mirabegron in Healthy Korean Participants. [PDF]

Drug Des Devel Ther
Ryu H, Cho JY, Lee DY, Lee S.
europepmc   +1 more source