Results 231 to 240 of about 26,645,245 (287)

First-in-Human Phase I Study of KPT-9274, a First-in-Class Dual Inhibitor of PAK4 and NAMPT, in Patients with Advanced Solid Malignancies. [PDF]

Target Oncol
Razak A, Mahipal A, Diamond JR, Ribas A, Berlin JD, Azmi AS, Mark T, Walker CJ, Chai Y, Kashyap T, Gudi G, Naing A.   +11 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Drug Reaction with Eosinophilia and Systemic Symptoms in the Electronic Medical Record.

Int Arch Allergy Immunol
Jiang M, Lam L, Kovoor J, Inglis JM, Shakib S, Yuson C, Ali SB, Bacchi S, Kern JS, Sidhu S, Smith W.   +10 more
europepmc   +1 more source

Pexidartinib: Current advances in the symptomatic treatment of tenosynovial giant cell tumors. [PDF]

Cancer Metastasis Rev
Yuan Y, Zhang Z, Jiang Y, Ye T, Chen J.
europepmc   +1 more source

Cartooning in Biological Learning. [PDF]

Biochem Mol Biol Educ
Bahsoun S, Morris M, Akam E.
europepmc   +1 more source

Challenges of the Inflation Reduction Act for long-term care pharmacy: Examining impact and policy solutions. [PDF]

J Manag Care Spec Pharm
Bhardwaj S, Schmutz HW, Watanabe JH, Barthold D.   +3 more
europepmc   +1 more source

The genome of a low-seeded mandarin, Premier, displays major structural changes due to gamma irradiation. [PDF]

Plant Genome
Nakandala U, Furtado A, Henry RJ.
europepmc   +1 more source

Correction to "Health Equity in Systematic Reviews: A Tutorial-Part 1 Getting Started With Health Equity in Your Review", "Health Equity in Systematic Reviews: A Tutorial-Part 2 Implementing Health Equity Throughout Your Methods", "Meta-Analysis Using Time-to-Event Data: A Tutorial" and "Split Body Trials in Systematic Reviews and Meta-Analyses: A Tutorial". [PDF]

Cochrane Evid Synth Methods
europepmc   +1 more source