Results 141 to 150 of about 14,775 (232)

Making sense of invisible densities in single-particle cryo-EM. [PDF]

IUCrJ
Lin X, Cheng Y.
europepmc   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Organ-preserving management of chronic renal hydatid cyst with 10-year asymptomatic progression: a case report. [PDF]

BMC Nephrol
Luo B, Fang K, Zhong S, Di W.
europepmc   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

The protective model of myofascial trigger points: a testable systems-level framework based on strain-repair mismatch. [PDF]

Front Physiol
Strickland M, Luera MJ, Parra ME, Riggs C.   +3 more
europepmc   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

CoSMIC: A hybrid approach for large-scale, high-resolution microbial profiling of novel niches. [PDF]

PLoS One
Knafo M, Rezenman S, Idan T, Elgart M, Dagan S, Zavaro V, Reich Z, Kapon R, Sade D, Shental N.   +9 more
europepmc   +1 more source

In Situ Local Resistance Analysis of Mechanical Degradation in All‐Solid‐State Batteries

Advanced Science, EarlyView.
In this study, we developed an in situ scanning spreading resistance microscopy technique for all‐solid‐state batteries using sulfide solid electrolytes to visualize the evolution of local electronic resistance in NCM‐based cathode composites during charging.
Hirotada Gamo, Yasushi Maeda, Yuji Yamagishi, Tetsu Kiyobayashi, Naoya Ishida, Zyun Siroma, Kentaro Kuratani, Nobuhiko Takeichi, Hikaru Sano   +8 more
wiley   +1 more source

An expectile-based framework for risk-calibrated credible capacity evaluation of virtual power plants under wind and PV forecast uncertainties. [PDF]

Sci Rep
Hua D, Zeng J, Lin Q, Cui S, Liu Y, Liang Y.   +5 more
europepmc   +1 more source

A VIO-aided partial ambiguity resolution for RTK positioning in complex urban environments

GPS Solutions
Qishun Ran, Gang Liu, Zongqi Yu, Yiding Zhan, Xiaowei Cui, Mingquan Lu   +5 more
openaire   +1 more source