Results 61 to 70 of about 396,888 (285)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Three-dimensional analysis of prebunched electron beams in an x-ray free-electron laser

Physical Review Special Topics. Accelerators and Beams, 2012
The effect of partial prebunching of an electron beam on the saturation length, efficiency, and longitudinal coherence is studied for a nominal x-ray free-electron laser design.
H. P. Freund, D. C. Nguyen, B. Carlsten
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Statistical-Mechanical Measure of Stochastic Spiking Coherence in A Population of Inhibitory Subthreshold Neurons

, 2011
By varying the noise intensity, we study stochastic spiking coherence (i.e., collective coherence between noise-induced neural spikings) in an inhibitory population of subthreshold neurons (which cannot fire spontaneously without noise).
A Longtin, A Longtin, AL Hodgkin, B Hauschildt, C Börgers, C Börgers, C Morris, C Vreeswijk, CM Gray, D Golomb, D Hansel, D Hansel, EM Izhikevich, G Buzsáki, G Buzsáki, J Freund, J Rinzel, J White, K Tsumoto, L Gammaitoni, M San Miguel, MA Whittington, N Brunel, N Brunel, N Brunel, P Grosse, P Tass, PHE Tiesinga, RE Mirollo, S Schreiber, Sang-Yoon Kim, SC Manrubia, W Lim, W Lim, Woochang Lim, X-J Wang, X-J Wang, X-J Wang, Y Kuramoto, Y Wang, ZF Mainen   +40 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Change of decoherence scenario and appearance of localization due to reservoir anharmonicity

, 2005
Although coupling to a super-Ohmic bosonic reservoir leads only to partial dephasing on short time scales, exponential decay of coherence appears in the Markovian limit (for long times) if anharmonicity of the reservoir is taken into account. This effect
E. Joos, E. M. Lifshitz, G. Alber, G. D. Mahan, H.-P. Breuer, M. A. Nielsen, Paweł Machnikowski   +6 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Coherent diffusion of partial spatial coherence

Optica, 2019
Partially coherent light is abundant in many physical systems, and its propagation properties are well understood. Here we extend current theory of propagation of partially coherent light beams to the field of coherent diffusion. Based on a unique four-wave mixing scheme of electro-magnetically induced transparency, an optical speckle pattern is ...
Ronen Chriki, Slava Smartsev, David Eger, Ofer Firstenberg, Nir Davidson   +4 more
openaire   +2 more sources

Linear algebraic theory of partial coherence: discrete fields and measures of partial coherence [PDF]

Journal of the Optical Society of America A, 2002
A linear algebraic theory of partial coherence is presented that allows precise mathematical definitions of concepts such as coherence and incoherence. This not only provides new perspectives and insights but also allows us to employ the conceptual and algebraic tools of linear algebra in applications. We define several scalar measures of the degree of
Ozaktas, H., M., Yüksel, S., Kutay, M.A.   +2 more
openaire   +8 more sources