Results 61 to 70 of about 1,741,957 (288)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Why There Cannot be a Single Probabilistic Measure of Coherence [PDF]

, 2005
Bayesian Coherence Theory of Justification or, for short, Bayesian Coherentism, is characterized by two theses, viz. (i) that our degree of confidence in the content of a set of propositions is positively affected by the coherence of the set, and (ii ...
Bovens, Luc, Bovens, L, Hartmann, Stephan   +2 more
core   +1 more source

Closed-form Fresnel analysis of double-slit diffraction with multi-wave coherent illumination

Frontiers in Photonics
IntroductionDouble-slit diffraction remains a foundational problem in wave optics, but most closed-form treatments assume single-wave illumination. In many modern optical systems, multi-wave coherent illumination is used to tailor the spatial spectrum of
J. Sumaya-Martínez, M. A. Ortiz-Ferreyro, O. Rojas-Hernandez   +2 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Geometric interpretation of the three-dimensional coherence matrix for nonparaxial polarization [PDF]

, 2004
The three-dimensional coherence matrix is interpreted by emphasizing its invariance with respect to spatial rotations. Under these transformations, it naturally decomposes into a real symmetric positive definite matrix, interpreted as the moment of ...
Dennis, MR, Dennis, M.R., Dennis, M R; id_orcid   +2 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Superresolution of two unbalanced point sources assisted by the entangled partner

Physical Review Research, 2022
Sub-diffraction-limit resolution, or superresolution, has been successfully demonstrated in recent theoretical and experimental studies for two equal-brightness and incoherent point sources.
Abdelali Sajia, Xiao-Feng Qian
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Three-dimensional analysis of prebunched electron beams in an x-ray free-electron laser

Physical Review Special Topics. Accelerators and Beams, 2012
The effect of partial prebunching of an electron beam on the saturation length, efficiency, and longitudinal coherence is studied for a nominal x-ray free-electron laser design.
H. P. Freund, D. C. Nguyen, B. Carlsten
doaj   +1 more source