Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Ocrelizumab (OCR), a humanized anti‐CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR‐MS). We assessed early cellular B‐cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation.
Alexandra Garcia +20 more
wiley +1 more source
Note on the Solution of Partial Differential Equations by the Method of Reciprocation [PDF]
, 1892 John M'Cowan
openalex +1 more source
The Road Not Taken: Misclassifying an Anti‐Seizure Medication as a Failure
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To quantify how often anti‐seizure medications (ASMs) appear ineffective yet provide benefit when considering seizure frequency (SF) variability. Methods We used the CHOCOLATES seizure diary simulator to generate 100,000 patient seizure diaries that reflect natural SF variation in a heterogeneous population.
Christopher N. Henry +1 more
wiley +1 more source
Partial differential equation models for invasive species spread in the presence of spatial heterogeneity. [PDF]
PLoS OneHughes EH +3 more
europepmc +1 more source
The Solution of Partial Differential Equations of the Second Order, with any number of variables, when there is a general first integral [PDF]
, 1875 H. W. Lloyd Tanner
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos +17 more
wiley +1 more source
Note on a Set of Special Classes of Partial Differential Equations of the Second Order [PDF]
, 1908 Andrew Russell Forsyth
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Prognostication of disease course and prediction of treatment response in multiple sclerosis is an unmet need. We compared the performance of serum neurofilament light chain Z scores (age‐ and BMI‐adjusted) with absolute concentrations for the prediction of response to disease‐modifying therapy.
Maximilian Einsiedler +43 more
wiley +1 more source
Risk factors in the illness-death model: Simulation study and the partial differential equation about incidence and prevalence. [PDF]
PLoS One, 2019 Hoyer A, Kaufmann S, Brinks R.
europepmc +1 more source
On Differential Equations, Total and Partial; and on a New Soluble Class of the First and an Exceptional Case of the Second [PDF]
, 1878 James Cockle
openalex +1 more source