Results 31 to 40 of about 159,465 (264)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Partial equilibrium model – Case study of the poultry market

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2011
This paper deals with identifying the main determinants in the poultry agri-food chain in the Czech Republic and examines their relationships. The partial equilibrium model, defined as a seven-equation model in power form, is employed for this purpose ...
Lenka Šobrová, M. Malý, Z. Malá
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Dynamics of a Virological Model for Cancer Therapy with Innate Immune Response

Complexity, 2020
The aim of this work is to present a virological model for cancer therapy that includes the innate immune response and saturation effect. The presented model combines both the evolution of a logistic growing tumor and time delay which stands for the ...
Ayoub Nouni, Khalid Hattaf, Noura Yousfi
doaj   +1 more source

Heterogeneous Phases Reaction Equilibrium in an Oxy-Thermal Carbide Furnace

ChemEngineering, 2020
This work focuses on revealing the chemical reaction equilibrium behaviors of gas−liquid−solid heterogeneous phases in an oxy-thermal carbide furnace.
Wenjie Xiong, Xiaohui Chen, Quanyong Wang, Min Gao, Danxing Zheng, Yuliang Mai, Wei Hu   +6 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

EVALUATION OF PRICE POLICY ON THE MOST IMPORTANT CEREAL CROP [PDF]

Arab Universities Journal of Agricultural Sciences, 2016
The research aimed at studying current situation improvement for grain crops production to meet international and domestic demand needs regularly with stable prices and standard specification, through analysis and assessment Egyptian price policy for ...
Wafaa Eid, Shahira Ibrahim
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Duality results for interval-valued semiinfinite optimization problems with equilibrium constraints using convexificators

Journal of Inequalities and Applications, 2022
This paper deals with the study of interval-valued semiinfinite optimization problems with equilibrium constraints (ISOPEC) using convexificators. First, we formulate Wolfe-type dual problem for (ISOPEC) and establish duality results between the (ISOPEC)
K. K. Lai, S. K. Mishra, Mohd Hassan, Jaya Bisht, J. K. Maurya   +4 more
doaj   +1 more source