Results 41 to 50 of about 1,004,302 (303)
Heterogeneous Phases Reaction Equilibrium in an Oxy-Thermal Carbide Furnace
ChemEngineering, 2020 This work focuses on revealing the chemical reaction equilibrium behaviors of gas−liquid−solid heterogeneous phases in an oxy-thermal carbide furnace.
Wenjie Xiong +6 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Dynamics of a Virological Model for Cancer Therapy with Innate Immune Response
Complexity, 2020 The aim of this work is to present a virological model for cancer therapy that includes the innate immune response and saturation effect. The presented model combines both the evolution of a logistic growing tumor and time delay which stands for the ...
Ayoub Nouni, Khalid Hattaf, Noura Yousfi
doaj +1 more source
Journal of Inequalities and Applications, 2022 This paper deals with the study of interval-valued semiinfinite optimization problems with equilibrium constraints (ISOPEC) using convexificators. First, we formulate Wolfe-type dual problem for (ISOPEC) and establish duality results between the (ISOPEC)
K. K. Lai +4 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Comparing open and closed molecular self-assembly [PDF]
, 2014 We study theoretically in the present work the self-assembly of molecules in an open system, which is fed by monomers and depleted in partial or complete clusters. Such a scenario is likely to occur for example in the context of viral self-assembly.
Castelnovo, Martin +2 more
core +6 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Advances in Difference Equations, 2017 This paper is concerned with a non-zero sum differential game problem of an anticipated forward-backward stochastic differential delayed equation under partial information.
Yi Zhuang
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source