Results 41 to 50 of about 893,803 (305)

Economic incentives modify agricultural impacts of nuclear war

Environmental Research Letters, 2022
A nuclear war using less than 1% of the current global nuclear arsenal, which would inject 5 Tg of soot into the stratosphere, could produce climate change unprecedented in recorded human history and significant impacts on agricultural productivity and ...
Gal Hochman, Hainan Zhang, Lili Xia, Alan Robock, Aleti Saketh, Dominique Y van der Mensbrugghe, Jonas Jägermeyr   +6 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Analysis of Non-Equilibrium and Equilibrium Models of Heat and Moisture Transfer in a Wet Porous Building Material

Energies, 2020
In the proposed paper, non-equilibrium and equilibrium models of heat and moisture transfer through wet building materials are presented and compared.
Mirosław Seredyński, Michał Wasik, Piotr Łapka, Piotr Furmański, Łukasz Cieślikiewicz, Karol Pietrak, Michał Kubiś, Tomasz S. Wiśniewski, Maciej Jaworski   +8 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

O sistema geral de preferências dos EUA: uma estimativa dos impactos sobre as exportações brasileiras The U.S. generalized system of preferences: an estimate of the impacts on brazilian exports

Revista de Economia Contemporânea, 2010
O Sistema Geral de Preferências (SGP) dos EUA, concedido de forma unilateral, é um dos programas com tarifa preferencial mais importantes para o Brasil, mas recentemente vem sendo objeto de apreensão devido às ameaças de exclusão do Brasil entre os ...
Natalia Paiva do Nascimento Visconti, Honorio Kume   +1 more
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Dynamic asset risk-seeking insider trading under signal observation

AIMS Mathematics
In this paper, we investigated a continuous version of an insider trading model. There were three basic assumptions in this model: (1) the insider exhibited risk-seeking, (2) market makers could receive partial signals regarding the risky asset, and (3 ...
Kai Xiao
doaj   +1 more source

The shear viscosity of parton matter under anisotropic scatterings

European Physical Journal C: Particles and Fields, 2022
The shear viscosity $$\eta $$ η of a quark–gluon plasma in equilibrium can be calculated analytically using multiple methods or numerically using the Green–Kubo relation.
Noah M. MacKay, Zi-Wei Lin
doaj   +1 more source