Results 221 to 230 of about 5,933,507 (244)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Recognition of antitussive components in Farfarae Flos based on grey relational analysis and partial least squares regression. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Wu D, Lin X, Liu K, Ning H, Luo W, Zhao G.   +5 more
europepmc   +1 more source

Single–Atom Iron Sites Enable Enhanced Arsenic Removal From Water Through Synergistic Adsorption–Oxidation

Advanced Science, EarlyView.
Single–atom iron anchored on nitrogen–doped porous biochar exhibited ultra–efficient performance, exceptional environmental resilience, and integrated adsorption–oxidation functionality. The multifunctional architecture of the support and the unparalleled reactivity of single–atom iron underpinned the cooperative adsorption and oxidation of As(III ...
Tao Sun, Chao Wang, Shihang Wu, Xiaojia Zhou, Penggang Pei, Huijuan Yu, Yun Zhang, Qingqing Huang, Yuebing Sun   +8 more
wiley   +1 more source

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On the structure of partial least squares regression

Communications in Statistics Part B: Simulation and Computation, 1988
Inge Helland
exaly  

Sparse partial least squares regression for simultaneous dimension reduction and variable selection

Journal of the Royal Statistical Society Series B: Statistical Methodology, 2010
Hyonho Chun
exaly  

The peculiar shrinkage properties of partial least squares regression

Journal of the Royal Statistical Society Series B: Statistical Methodology, 2000
Neil A Butler
exaly  

Robust methods for partial least squares regression

Journal of Chemometrics, 2003
Mia Hubert
exaly  

libPLS: An integrated library for partial least squares regression and linear discriminant analysis

Chemometrics and Intelligent Laboratory Systems, 2018
Qingsong Xu, Hong-Dong Li, Yi-Zeng Liang
exaly  

An approach to interval estimation in partial least squares regression

Analytica Chimica Acta, 1993
Alexander Penlidis
exaly