Results 61 to 70 of about 876,733 (274)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Partial Least Squares: A Versatile Tool for the Analysis of High-Dimensional Genomic Data [PDF]
, 2005 Partial Least Squares (PLS) is a highly efficient statistical regression technique that is well suited for the analysis of high-dimensional genomic data.
Boulesteix, Anne-Laure +1 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Partial Least Squares Regression Performs Well in MRI-Based Individualized Estimations
Frontiers in Neuroscience, 2019 Estimation of individuals’ cognitive, behavioral and demographic (CBD) variables based on MRI has attracted much research interest in the past decade, and effective machine learning techniques are of great importance for these estimations.
Chen Chen, Xuyu Cao, Lixia Tian
doaj +1 more source
Chemical Engineering Transactions, 2020 With the goal of shaping a smart, economically-sustainable palm oil refining industry, this paper aims to improve the prediction modelling of Refined, Bleached and Deodorized Palm Oil (RBDPO) quality for early quality fault detection and remediation via ...
Wai Hoong Khu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Mining for genotype-phenotype relations in Saccharomyces using partial least squares
BMC Bioinformatics, 2011 Background Multivariate approaches are important due to their versatility and applications in many fields as it provides decisive advantages over univariate analysis in many ways.
Sæbø Solve +4 more
doaj +1 more source
Composite indices based on partial least squares [PDF]
, 2015 In this paper, we compare Principal Component Analysis (PCA) and Partial Least Squares (PLS) methods to generate weights for composite indices. In this context we also consider various treatments of non-metric variables when constructing such composite ...
Dreher, Axel +3 more
core
Key issues on partial least squares (PLS) in operations management research: A guide to submissions [PDF]
, 2019 Purpose: This work aims to systematise the use of PLS as an analysis tool via a usage guide or recommendation for researchers to help them eliminate errors when using this tool.
Alfalla Luque, Rafaela +1 more
core +4 more sources