Results 61 to 70 of about 3,984,806 (250)
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
A robust partial least squares method with applications [PDF]
Partial least squares regression (PLS) is a linear regression technique developed to relate many regressors to one or several response variables. Robust methods are introduced to reduce or remove the effect of outlying data points.
Javier Gonzalez +2 more
core
semPLS: Structural Equation Modeling Using Partial Least Squares
Journal of Statistical Software, 2012 Structural equation models (SEM) are very popular in many disciplines. The partial least squares (PLS) approach to SEM offers an alternative to covariance-based SEM, which is especially suited for situations when data is not normally distributed.
Armin Monecke, Friedrich Leish
doaj
Partial Least Squares Regression-Based Robust Forward Control of the Tableting Process
Pharmaceutics, 2020 In this study, we established a robust feed-forward control model for the tableting process by partial least squares regression using the near-infrared (NIR) spectra and physical attributes of the granules to be compressed.
Yusuke Hattori +2 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Partial Least Squares Regression on Symmetric Positive-Definite Matrices
Revista Colombiana de Estadística, 2013 Recientemente ha habido un aumento en el interés de analizar diferentes tipos de datos variedad-valuados, dentro de los cuáles aparecen los datos de matrices simétricas definidas positivas.
RAÚL ALBERTO PÉREZ +1 more
doaj
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Predictive model selection in partial least squares path modeling (PLS-PM) [PDF]
, 2015 Predictive model selection metrics are used to select models with the highest out-of-sample predictive power among a set of models. R2 and related metrics, which are heavily used in partial least squares path modeling, are often mistaken as predictive
Nidhi Sharma, Pratyush +7 more
core +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
The pls Package: Principal Component and Partial Least Squares Regression in R [PDF]
The pls package implements principal component regression (PCR) and partial least squares regression (PLSR) in R (R Development Core Team 2006b), and is freely available from the Comprehensive R Archive Network (CRAN), licensed under the GNU General ...
Björn-Helge Mevik, Ron Wehrens
core