Results 61 to 70 of about 232,548 (306)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Predictive model selection in partial least squares path modeling (PLS-PM)

, 2015
Predictive model selection metrics are used to select models with the highest out-of-sample predictive power among a set of models. R2 and related metrics, which are heavily used in partial least squares path modeling, are often mistaken as predictive
Nidhi Sharma, Pratyush, Pratyush Midhi Sharma, Shmueli, Galit, Sarstedt, Marko, Kim, Kevin H., Marko Sarstedt, Kevin H. Kim, Galit Shmueli   +7 more
core   +1 more source

Inferential control with the aid of modified QPLS-based soft sensor for an industrial FCCU fractionator [PDF]

, 2010
A modified quadratic partial least squares (MQPLS) algorithm based on non-linear constrained programming is proposed, in which a sequential unconstrained minimisation technique is employed to calculate the outer input weights and the parameters of inner ...
Yang, Minghui, Sheng Chen, Tu, Ling, Xuemin Tian, Chen, Sheng, Ling Tu, Tian, Xuemin, Minghui Yang   +7 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Use of Partial Least Squares Method To Remove Multicollinearity [PDF]

المجلة العراقية للعلوم الاحصائية, 2010
In this research the estimation of the regression parameters was clarified using least squares and partial least squares compared with the normal method in terms of its ability to be free from the problem of Multicollinearity between the predictive ...
doaj   +1 more source

Downscaling GRACE total water storage change using partial least squares regression

Scientific Data, 2021
Measurement(s) Gravity Technology Type(s) gravity field theory • computational modeling technique Factor Type(s) geographic location • temporal interval Sample Characteristic - Environment water body Sample Characteristic - Location global Machine ...
Bramha Dutt Vishwakarma, Jinwei Zhang, Nico Sneeuw   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

An integrated approach to the simultaneous selection of variables, mathematical pre-processing and calibration samples in partial least-squares multivariate calibration [PDF]

, 2013
A new optimization strategy for multivariate partial-least-squares (PLS) regression analysis is described. It was achieved by integrating three efficient strategies to improve PLS calibration models: (1) variable selection based on ant colony ...
Allegrini, Franco, Franco Allegrini, Alejandro C. Olivieri, Olivieri, Alejandro César   +3 more
core   +1 more source

A Partial Least Squares based algorithm for parsimonious variable selection

Algorithms for Molecular Biology, 2011
Background In genomics, a commonly encountered problem is to extract a subset of variables out of a large set of explanatory variables associated with one or several quantitative or qualitative response variables.
Mehmood Tahir, Martens Harald, Sæbø Solve, Warringer Jonas, Snipen Lars   +4 more
doaj   +1 more source

Using String Kernels to Identify Famous Performers from their Playing Style

, 2004
In this paper we show a novel application of string kernels: that is to the problem of recognising famous pianists from their style of playing. The characteristics of performers playing the same piece are obtained from changes in beat-level tempo and ...
David R. Hardoon, Shawe-Taylor, John, John Shawe-taylor, Saunders, Craig, Hardoon, David R., Gerhard Widmer, Craig Saunders, Widmer, Gerhard   +7 more
core   +1 more source