Results 71 to 80 of about 1,115,339 (315)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The History of Partial Order Planning and RubyPOP
, 2008 For our case, we'll explore partial-order planning in a classical planning environment. Such an environment is fully observable (as opposed to only partially so) and deterministic (as opposed to having randomness, or being stochastic).
What Is Partial-order Planning +1 more
core
Constrained Dynamic Partial Order Reduction
, 2018 The cornerstone of dynamic partial order reduction (DPOR) is the notion of independence that is used to decide whether each pair of concurrent events p and t are in a race and thus both p · t and t · p must be explored.
Isabel Márquez, Miguel +3 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Lix: An Effective Self-applicable Partial Evaluator for Prolog [PDF]
, 2004 This paper presents a self-applicable partial evaluator for a considerable subset of full Prolog. The partial evaluator is shown to achieve non-trivial specialisation and be effectively self-applied.
Stephen-John Craig +3 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Partial Order Reduction with Compositional Verification
, 2014 This thesis expands the usage of partial order reduction methods in reducing the state space of large models in model checking. The work done can be divided into two parts.
Shaw, Adrian Mark
core
Logic program specialisation through partial deduction: Control Issues
, 2002 Program specialisation aims at improving the overall performance of programs by performing source to source transformations. A common approach within functional and logic programming, known respectively as partial evaluation and partial deduction, is to ...
Bruynooghe, Maurice, Leuschel, Michael
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source