Results 51 to 60 of about 3,793,270 (189)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Power Enhancement under Partial Shading Condition Using a Two-Step Optimal PV Array Reconfiguration

International Journal of Photoenergy, 2021
Under partial shading conditions, photovoltaic (PV) arrays are subjected to different irradiance levels caused by nonuniform shading. As a result, a mismatch between the modules, a reduction in the power generated, and the hotspot phenomenon will be ...
Mohamad Hossien Nahidan, Mehdi Niroomand, Behzad Mirzaeian Dehkordi   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Improved RCC-Based MPPT Strategy for Enhanced Solar Energy Harvesting in Shaded Environments

IEEE Access
An improved ripple correlation control (iRCC) algorithm is proposed to enable conventional ripple correlation control (cRCC) to track maximum power under uniform and partial shading condition (PSC). The proposed iRCC has two parts; the first part detects
Hamid Khan, Hadeed Ahmed Sher, Afaq Hussain, Abdullah M. Noman, Ali Faisal Murtaza, Kareem M. AboRas   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Enhancing Global Maximum Power Point of Solar Photovoltaic Strings under Partial Shading Conditions Using Chimp Optimization Algorithm

Energies, 2021
This paper proposes the application of a metaheuristic algorithm inspired by the social behavior of chimps in nature, called Chimp Optimization Algorithm (ChOA), for the maximum power point tracking of solar photovoltaic (PV) strings.
Timmidi Nagadurga, Pasumarthi Venkata Ramana Lakshmi Narasimham, V. S. Vakula, Ramesh Devarapalli, Fausto Pedro García Márquez   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Lipschitz Optimization-Based MPPT Algorithm for Photovoltaic System Under Partial Shading Condition

IEEE Access, 2019
The power–voltage curve of a photovoltaic (PV) array shows multiple power peaks under partially shading conditions (PSCs). Hence, conventional maximum power point tracking (MPPT) algorithms can not guarantee the maximum power output of the PV ...
Wenfan Li, Guogang Zhang, Tingzhe Pan, Zeyu Zhang, Yingsan Geng, Jianhua Wang   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source