Results 51 to 60 of about 9,770 (261)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Lipschitz Optimization-Based MPPT Algorithm for Photovoltaic System Under Partial Shading Condition

IEEE Access, 2019
The power–voltage curve of a photovoltaic (PV) array shows multiple power peaks under partially shading conditions (PSCs). Hence, conventional maximum power point tracking (MPPT) algorithms can not guarantee the maximum power output of the PV ...
Wenfan Li, Guogang Zhang, Tingzhe Pan, Zeyu Zhang, Yingsan Geng, Jianhua Wang   +5 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Hybrid PSO-Incremental Conductance MPPT for Induction Motor based Solar Water Pumping System under Partial Shading Conditions

Advances in Electrical and Computer Engineering, 2023
The solar water pumping systems (SWPS) is useful in remote or village areas where there is no electricity. In India, SWPS are revolutionizing agriculture by giving farmers access to power for everything, from harvesting crops to pumping water.
SHETTY, D., SABHAHIT, J. N., MUDLAPUR, A., HEBBAR, P.   +3 more
doaj   +1 more source

A New MPPT Algorithm for Photovoltaic Power Generation under Uniform and Partial Shading Conditions

Energies, 2021
During its operation, a photovoltaic system may encounter many practical issues such as receiving uniform or non-uniform irradiance caused mainly by partial shading.
Novie Ayub Windarko, Muhammad Nizar Habibi, Bambang Sumantri, Eka Prasetyono, Moh. Zaenal Efendi, Taufik   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Analysis of Dynamic Characteristic for Solar Arrays in Series and Global Maximum Power Point Tracking Based on Optimal Initial Value Incremental Conductance Strategy under Partially Shaded Conditions

Energies, 2017
Partial shading (PS) is an unavoidable condition which significantly reduces the efficiency and stability of a photovoltaic (PV) system. With PS, the system usually exhibits multiple-peak output power characteristics, but single-peak is also possible ...
Jian Zhao, Xuesong Zhou, Youjie Ma, Yiqi Liu   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Event-Driven, Condition-Aware MPPT Framework for Robust Tracking Under Partial Shading and Dynamic Irradiance

IEEE Access
Partial shading conditions (PSC) introduce multiple peaks in photovoltaic P-V characteristics, causing conventional MPPT algorithms to converge prematurely at local maxima.
Youcef Souda, Masafumi Miyatake
doaj   +1 more source