Results 51 to 60 of about 8,916,298 (287)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A zero switch and sensorless reconfiguration approach for sustainable operation of roof‐top photovoltaic system during partial shading

IET Renewable Power Generation, 2023
Photovoltaic (PV) roof‐top systems in real‐time environments are highly susceptible to the commonly occurring scenario of partial shading that occurs due to unavoidable conditions such as the shadow of buildings and trees.
Belqasem Aljafari, Priya Ranjan Satpathy, Sudhakar Babu Thanikanti, Hassan Haes Alhelou   +3 more
doaj   +1 more source

Analysis of single-cell shading impact on polycrystalline PERC module under hot-dry conditions

Energy Conversion and Management: X
PV technologies may often perform differently under outdoor operating conditions compared with Standard Test Conditions, which are performed under a controlled setup inside a laboratory.
Neha Kumari, Sanjay Kumar Singh, Sanjay Kumar, Vinay Kumar Jadoun   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The Effect of Partial Shadings on the Output Power of the Photovoltaic Modules Connected with Different Current and Voltage Characteristics

Jurnal Rekayasa Elektrika
A mismatch in the output power of photovoltaic (PV) modules in a PV array can occur due to partial shading or a module replacement. Substitution of a module in a PV array with a new one might lead to different current and voltage characteristics between ...
Ira Devi Sara, Aidil Aqsa SH, Tarmizi Tarmizi   +2 more
doaj   +1 more source

A new algorithm described PV module’s behavior under partial shading conditions

Revue des Énergies Renouvelables, 2022
The shadowing of a single cell in string leads to reverse bias of the shadowed cell. The cell acts as a load instead of a generator in order to deal with this effect and the hotspots problems, this paper focuses on the design of bypass diodes ...
Houssem Saber, Abdelouadoud Bendaoud, Hammoud Radjeai, Lazhar Rahmani   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A Long-Term Condition Monitoring and Performance Assessment of Grid Connected PV Power Plant with High Power Sizing Factor under Partial Shading Conditions

Energies, 2020
Partial shading conditions of photovoltaic (PV) modules often occurs in urban areas leading to losses in electricity power generation of the PV power plant.
Zoltan Corba, Bane Popadic, Dragan Milicevic, Boris Dumnic, Vladimir A. Katic   +4 more
doaj   +1 more source