Results 81 to 90 of about 1,330,765 (292)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Partially coherent twisted states in arrays of coupled phase oscillators [PDF]

, 2013
We consider a one-dimensional array of phase oscillators with non-local coupling and a Lorentzian distribution of natural frequencies. The primary objects of interest are partially coherent states that are uniformly "twisted" in space.
Oleh E. Omel'chenko, Omel'chenko, Oleh, Matthias Wolfrum, Laing, Carlo, Carlo R. Laing, Wolfrum, Matthias   +5 more
core   +1 more source

Coupling Efficiency of a Partially Coherent Radially Polarized Vortex Beam into a Single-Mode Fiber

Applied Sciences, 2018
We study the problem of coupling partially coherent radially polarized (PCRP) vortex beams into a single-mode optical fiber. Using the well-known concept of the cross-spectral density (CSD) matrix, we derive a general expression for the coupling ...
Xinlei Zhu, Kuilong Wang, Fei Wang, Chengliang Zhao, Yangjian Cai   +4 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

High-dynamic-range imaging optical detectors [PDF]

, 2002
Imaging spectrometers allowing spatially resolved targets to be spectrally discriminated are valuable for remote sensing and defense applications. The drawback of such instruments is the need to quickly process very large amounts of data.
Coutinho, R.C., Selviah, D.R., Griffiths, H.D.   +2 more
core  

Spatial-Temporal Self-Focusing of Partially Coherent Pulsed Beams in Dispersive Medium

Applied Sciences, 2019
Partially coherent pulsed beams have many applications in pulse shaping, fiber optics, ghost imaging, etc. In this paper, a novel class of partially coherent pulsed (PCP) sources with circular spatial coherence distribution and sinc temporal coherence ...
Zhiguo Zhao, Chaoliang Ding, Yongtao Zhang, Liuzhan Pan   +3 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Free-Space Optical Communication Systems with a Partially Coherent Gaussian Beam and Media Diversity [PDF]

Terrestrial free-space optical (FSO) communications is an emerging low-license-free and high-bandwidth access solution, albeit hampered by the combined effects from atmospheric loss, turbulence and pointing errors (PEs).
Lee, It Ee
core