Results 121 to 130 of about 514,221 (275)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Etnografía virtualizada: la observación participante y la entrevista semiestructurada en línea [PDF]

open access: yesAthenea Digital, 2003
From our ethnographic experience in chats, for the study "Entre Dones a la Xarxa: Un estudi sobre les interaccions socials entre dones en espais de conversa electronics", we try to question those methodological approaches to the virtual areas that adapt ...
Ardèvol, Elisenda   +3 more
doaj  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Review: Rainer Wettreck (1998). "Arzt sein – Mensch bleiben": Eine Qualitative Psychologie des Handelns und Erlebens in der modernen Medizin ["Being a Doctor—Staying Human": A Qualitative Psychology of Acting and Experiencing in Modern Medicine]

open access: yesForum: Qualitative Social Research, 2002
The book "Arzt sein – Mensch bleiben": Eine Qualitative Psychologie des Handelns und Erlebens in der modernen Medizin by Rainer WETTRECK gives a comprehensive description of the conditions under which doctors act professionally at times of death or other
Werner Vogd
doaj  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Slow journalism: a letter to ethnographers

open access: yesFrontiers in Sociology, 2023
Ted Conover
doaj   +1 more source

'You Don't Know How Lucky You Are to Be Here!': Reflections on Covert Practices in an Overt Participant Observation Study [PDF]

open access: yes
There has been a tendency in sociology to see covert and overt roles of social researchers in participant observation studies as opposites. This is both in terms of the researcher role and the surrounding ethics, with the overt researcher role being seen
John S. McKenzie
core  

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