Results 211 to 220 of about 9,995 (264)

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Global overview of multiple sclerosis care units: an international cross-sectional survey. [PDF]

Front Neurol
Sörensen PS, Zaratin PF, Battaglia MA, Edan G, Samadzadeh S, Leocani L, Becker J, Flores J, Hamuy F, Cristiano E, Patrucco L, Montalbán X, Hartung HP, Comi G, Fernandez OF.   +14 more
europepmc   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Knowledge and perceptions of donor human milk among university health sciences students in southern Ecuador: a cross-sectional study. [PDF]

Front Glob Womens Health
Rojas-Rodríguez AL, Imaicela JD, Contreras JI, Quiroz JA.   +3 more
europepmc   +1 more source

Analysis of Financial Crowding Out in the Iraqi Economy for the Period 2004 - 2022. [PDF]

F1000Res
Jabbar A, Dikheel B.
europepmc   +1 more source

Innovations in Corneal Transplantation: The Role of Eye Banks, Donor Corneas, and Artificial Alternatives in Combating Worldwide Corneal Blindness. [PDF]

Rom J Ophthalmol
Chandra M, Singh J, Dubey G, Pandey GG, Jha A.   +4 more
europepmc   +1 more source

Making economic citizens beyond neoliberalism: Historical trajectories of a banker association's efforts in economic education. [PDF]

Eur Educ Res J
Ruoss T.
europepmc   +1 more source

Environmental management accounting affects bank performance with mediators. [PDF]

PLoS One
Nguyen KQT.
europepmc   +1 more source

Audit of pre-transfusion testing practices in hospital blood banks across Tanzania: A national survey. [PDF]

Afr J Lab Med
Mwashiuya OF, Lyimo MA, Mogela DJ, Bhombo AJ, Mwimo JL, Shewiyo EJ, Tingo BN.   +6 more
europepmc   +1 more source