Results 41 to 50 of about 38,671 (261)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Socioeconomic Factors Affecting Youth Participation in Forest-Based Enterprises in Ibadan, Nigeria [PDF]

Journal of Agriculture and Rural Development Studies
This study examines the socioeconomic factors affecting youth participation in forest-based enterprises in Ibadan. The research is motivated by the persistent challenge of youth unemployment and the need to explore sustainable livelihood opportunities ...
Olajumoke Celinah Odeyale, Olaoluwa Ayodeji Adebayo, Eseoghene Bridget Olawuyi, Ibiyinka Olubukola Ademiluyi   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Analisis Faktor-Faktor yang Memengaruhi Keputusan Penyedia untuk Memasukkan Penawaran pada Tender Pekerjaan Konstruksi di Kementerian Keuangan

Jurnal Wacana Kinerja, 2020
The participation level of the construction-work provider tender within the Ministry of Finance did not reach the target. In 2017, the expected participation index was 5, but it was only 4.5 in reality.
Bambang Sancoko, Bary Rachman Pratama
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

THE CHALLENGING FACTORS AFFECTING WOMEN ENTREPRENEURIAL ACTIVITIES

Journal of Liberty and International Affairs, 2022
The purpose of this study is to investigate the factors such as access to finance, legal constraints, and entrepreneurial skill on women's participation in business activities.
Rimsha Khalid, Mohsin Raza, Anusara Sawangchai, Chanyanan Somtawinpongsai   +3 more
doaj  

COVID-19 and participatory budgeting in North Macedonia and Slovakia

Public Sector Economics, 2023
The practice of fostering citizen participation in public finance-related decision making at local government level in North Macedonia and Slovakia has backslid during COVID-19.
Mária Murray Svidroňová, Marjan Nikolov, Vesna Garvanlieva Andonova   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

LEVERAGING BIG DATA TECHNOLOGIES FOR ENHANCED PUBLIC PARTICIPATION IN PUBLIC FINANCIAL MANAGEMENT

Фінансово-кредитна діяльність: проблеми теорії та практики
The article is devoted to the topical issues regarding the implementation of Big Data technologies in public finance management. The application of Big Data has the potential to enhance transparency and accountability in the use of budgetary resources ...
Sergii Krynytsia, Oksana Hordei, Yuliia Kovalenko, Alla Dankevych, Andrii Boldov   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source