Results 71 to 80 of about 36,711 (196)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Legal forms of participation of institutions of development in the organization of project finance scheme in Russia

Ученые записки Российской академии предпринимательства, 2021
This article is devoted to the important topic of project financing. The author reveals the concept of project finance and analyzes in detail legal forms and targets of participation of institutions of development in project financing scheme based on ...
S. V. Kuznetsov
doaj  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

La finance participative

Calenda, 2014
La promulgation des statuts de conseiller en investissement participatif et d'intermédiaire en investissement participatif, le 31 mai 2014, renouvelle le questionnement juridique sur les micro-financements dématérialisés. Les chercheurs du Centre René Demogue du CRDP y consacrent une journée d'étude le 26 juin, en salle Guy Debeyre de la faculté des ...
openaire   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Can major public health emergencies increase the participation of commercial insurance? Evidence from China

Frontiers in Public Health
BackgroundPublic health emergencies have a lasting impact on a country's economic and social development. However, commercial insurance can disperse these negative consequences and reduce risk losses.MethodBased on the Chinese Household Tracking Survey ...
Yiqiu Wang, Chong Guo, Yang Xu, Meng Xie
doaj   +1 more source

Descentralização e endividamento municipal: formas, limites e possibilidades
Decentralization and municipal indebtedness: modes, constraints, and possibilities [PDF]

Nova Economia, 2002
The objective of this article is to discuss alternatives to finance investments by municipalities. In general, current revenues are insufficient to finance large investments, what brings about the necessity of municipal indebtedness.
Amaury Patrick Gremaud, Rudinei Toneto Jr   +1 more
doaj  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The federation's participation in financing sports and leisure in Brazil

PODIUM Sport, Leisure and Tourism Review, 2021
Objective of the study: To analyze the financing of the Sport and Leisure Function (SLF) by the Municipalities, States/Distrito Federal (DF) and the Union from 2013 to 2018.Methodology/approach: Qualitative descriptive-exploratory research with documentary analysis based on data from the Sistema de Informações Contábeis e Fiscais do Setor Público ...
Carneiro, Fernando Henrique Silva, Athayde, Pedro Fernando Avalone, Mascarenhas, Fernando   +2 more
openaire   +1 more source