Results 71 to 80 of about 356,702 (245)

A Framework for Resident Participation in Population Health

open access: yesAcademic Medicine, 2019
Population health experiences have become more common in medical education. Yet, most resident population health experiences are in patient panel management and fail to connect with the rapidly growing movement of cross-sector, data-driven, and community-led initiatives dedicated to improving the health of populations defined by geography rather than ...
Jiménez, Jonathan   +3 more
openaire   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Participation frameworks for computer mediated communication

open access: yes, 1991
This paper is concerned with the development of a more complex view of the analysis of social interactions in CMC systems. There is an apparent paradox in findings of previous studies of text-based CMC which may be due to the nature of this type of communication for it requires users to orient to two models: conversation and text.
Jirotka, M, Luff, P, Gilbert, N
openaire   +2 more sources

Croatia’s participation in the Seventh Framework Programme: a Moderate Success?

open access: yesBusiness Systems Research, 2013
Background: The Framework Programme (FP7) is the main instrument of the EU for financing research, and participation in the programme benefits greatly to countries’ technological development.
Mataković Hrvoje, Novak Iva Radočaj
doaj   +1 more source

Public Participation in Scientific Research: a Framework for Deliberate Design

open access: yesEcology and Society, 2012
Members of the public participate in scientific research in many different contexts, stemming from traditions as varied as participatory action research and citizen science.
Jennifer L. Shirk   +10 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Urban Design and Planning Participation in the Digital Age: Lessons from an Experimental Online Platform

open access: yesSmart Cities
There is increasing use of digital technologies in urban planning, including in the generation of designs and the participative side of planning. We examine this digital planning by reporting on the application of an experimental online participatory ...
Stephen Marshall   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

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