Results 21 to 30 of about 4,334 (258)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Los modelos de democracia participativa en el constitucionalismo andino: los casos de Venezuela y Bolivia

Revista Vasca de Administración Pública, 2017
The Constitutions approved during the last two decades in the Andean zone of Latin America have created a constitutional form of their own, with elements different from traditional constitutionalism.
Albert Noguera Fernández
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Participatory Democracy in Reforming the Way of Political Organization of Contemporary Society - European Models

Історико-політичні проблеми сучасного світу, 2018
This article analyzes the phenomenon of participatory democracy and the impact of community norms on the process of democratization in the context of reforming the way of political organization of contemporary society.
Валентина Урсу
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Reforming the Relationship between the State and Civil Society in Latin America

Latin American Research Review, 2018
This essay reviews the following works: Enhancing Democracy: Public Policies and Citizen Participation in Chile. By Gonzalo Delamaza. New York: Berghahn Books, 2015. Pp. vi + 296. $99.00 hardcover. ISBN: 9781782385462. The Politics of Local Participatory
Maureen Donaghy
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Participação como representação: o impacto das conferências nacionais de políticas públicas no Congresso Nacional

Dados: Revista de Ciências Sociais, 2011
The relationship between representative democracy and participatory and deliberative experiences is not trivial. Those who endorse the discourse of a crisis in political representation sometimes defend participatory and deliberative modalities of ...
Thamy Pogrebinschi, Fabiano Santos
doaj   +1 more source

The Doctors of Democracy: Self-Image and Democratic Values of Participatory Practitioners

Journal of Deliberative Democracy, 2023
Against the backdrop of a perceived crisis of democracy, governments around the globe have extended citizens’ opportunities for public participation. Due to the increasing routinization of participatory processes, a vibrant participation industry has ...
Dennis Friess, Nina Katharina Herff
doaj   +2 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source