Results 181 to 190 of about 637,437 (230)
Advanced Science, EarlyView.This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang +5 more
wiley +1 more source
OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD
Advanced Science, EarlyView.This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li +11 more
wiley +1 more source
Advanced Science, EarlyView.After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin +9 more
wiley +1 more source
Participatory GIS approaches for mapping ecosystem services
, 2017 Fagerholm, Nora, Palomo, Ignacio
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Participatory GIS — a people's GIS?
Progress in Human Geography, 2007Recent years have witnessed a burgeoning of applications of GIS which grant legitimacy to indigenous geographical knowledge as well as to `official' spatial data. By incorporating various forms of community participation these newer framings of Geographical Information Systems as `Participatory GIS' (PGIS) offer a response to the critiques of GIS which
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Public participatory historical GIS
Historical Methods, 2019Building historical geographic information system (HGIS) datasets is time consuming and very expensive, especially when built at the scales that permit analysis of the lived experiences of individu...
Don Lafreniere +2 more
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Habitat International, 2003
Abstract The adoption of participatory spatial planning (PSP) approaches has been partially supported by developments in participatory-GIS (P-GIS), as seen in applications both in local resource management in developing South countries, and in community neighbourhood planning in the urban North.
Michael K McCall
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Abstract The adoption of participatory spatial planning (PSP) approaches has been partially supported by developments in participatory-GIS (P-GIS), as seen in applications both in local resource management in developing South countries, and in community neighbourhood planning in the urban North.
Michael K McCall
exaly +3 more sources
Cartography and Geographic Information Science, 2002
The recognition that local participation is a critical goal of development has contributed to the popularity in a set of techniques designed to increase local participation and knowledge in planning processes. Identified as participatory rural appraisal (PRA), this trend is marked by the use of a variety of high-end technologies, including geographic ...
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The recognition that local participation is a critical goal of development has contributed to the popularity in a set of techniques designed to increase local participation and knowledge in planning processes. Identified as participatory rural appraisal (PRA), this trend is marked by the use of a variety of high-end technologies, including geographic ...
exaly +2 more sources