Learning about social-ecological trade-offs
Trade-offs are manifestations of the complex dynamics in interdependent social-ecological systems. Addressing trade-offs involves challenges of perception due to the dynamics of interdependence.
Diego Galafassi +5 more
doaj +1 more source
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Centering and collaborating with community knowledge systems: piloting a novel participatory modeling approach. [PDF]
Shaikh Y +7 more
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
[Departement_IRSTEA]Eaux [TR1_IRSTEA]GEUSI ; International ...
Sendzimir, J. +5 more
openaire +1 more source
Participatory modeling from a stakeholder perspective: On the influence of collaboration and revisions on psychological ownership and perceived model quality. [PDF]
Gutschmidt A +5 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
ARDI: A Co-construction Method for Participatory Modeling in Natural Resources Management
The outcomes of a series of tests of the ARDI (Actors, Resources, Dynamics, and Interactions) method in complex cases or conflict-ridden situations is presented.
Michel Etienne +2 more
doaj +1 more source
Mapping the Complexity of Suicide by Combining Participatory Modeling and Network Science. [PDF]
Giabbanelli PJ +7 more
europepmc +1 more source

