Results 31 to 40 of about 8,685 (288)
PLoS ONE, 2019 BACKGROUND:System science approaches are increasingly used to explore complex public health problems. Quantitative methods, such as participatory dynamic simulation modelling, can mobilise knowledge to inform health policy decisions.
Louise Freebairn +5 more
doaj +1 more source
Health Research Policy and Systems, 2017 Background Evidence-based decision-making is an important foundation for health policy and service planning decisions, yet there remain challenges in ensuring that the many forms of available evidence are considered when decisions are being made ...
Louise Freebairn +7 more
doaj +1 more source
Participatory Simulation Framework for Agent-Based Model Validation in Air Traffic Management
, 2022 The EU Air Traffic Management (ATM) system is responsible for the safe and timely transportation of more than a billion passengers annually. It is a system that depends heavily on technology and is expected to stay on top of the technological ...
Lucía Herrero Álvarez +5 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
PaSyMo: Gamifying Communicative Urban Planning With Participatory Systems Modeling
Urban PlanningUrban planning increasingly requires navigating complex socio‐spatial dynamics and uncertainties, particularly when addressing social challenges where stakeholders hold diverse perspectives and knowledge.
Timo Szczepanska +3 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Des fonctions de la simulation des situations de travail en ergonomie
Activités, 2007 Ergonomic simulations may be classified according to the role that they assign to the future users, which may either be modelled in technical tools, subjects of controlled experiments, or participants in a participatory process.
François Daniellou
doaj +1 more source
Activity-based process construction for participatory geo-analysis
GIScience & Remote Sensing, 2021 Due to its advantages in participation and collaboration, participatory geo-analysis has been used for solving different types of geographical issues.
Zaiyang Ma +7 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Simulating future work activity is not only a way of improving workstation design
Activités, 2007 Ergonomic simulations may be classified according to the role that they assign to the future users, which may either be modelled in technical tools, subjects of controlled experiments, or participants in a participatory process.
François Daniellou
doaj +1 more source