Results 71 to 80 of about 3,910,500 (248)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Comprehensive organic emission profiles for gasoline, diesel, and gas-turbine engines including intermediate and semi-volatile organic compound emissions [PDF]

Atmospheric Chemistry and Physics, 2018
Emissions from mobile sources are important contributors to both primary and secondary organic aerosols (POA and SOA) in urban environments. We compiled recently published data to create comprehensive model-ready organic emission profiles for on- and off-
Q. Lu, Q. Lu, Y. Zhao, Y. Zhao, Y. Zhao, A. L. Robinson, A. L. Robinson   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

SIFAT FISIS PAPAN GYPSUM DARI LIMBAH GERGAJIAN KAYU

Jurnal Riset Industri Hasil Hutan, 2013
The purpose of this research is to exploit the waste ripsaw  as substitution of gypsum board on the fhysical of board gypsum. Raw material in the form of waste saw from particle of wood kambang (Goniothalamus Sp), wood tarap (Artocarpus Elasticus REINW ...
Saibatul Hamdi
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

PENGARUH JENIS KAYU DAN KOMPOSISI PEREKAT TAHAN CUACA TERHADAP SIFAT PAPAN PARTIKEL DUA JENIS KAYU HUTAN TANAMAN INDUSTRI

Jurnal Penelitian Hasil Hutan (Journal of Forest Products Research), 2017
This  paper  deals  with  an experiment   on  the effect of  two  timber  estate  wood  species  i.e. jeungjing  (Albizia.falcataria  Back),  tusam  (Pinus  merkusii Yung  et de  Vries)  and  the  composition   of  weather  resistance  resin  (phenol ...
Suwandi Kliwon, M I lskandar, Paribotro Sutigno Sutigno   +2 more
doaj   +1 more source

Galactic Cosmic-Ray Hydrogen Spectra in the 40–250 MeV Range Measured by the High-energy Particle Detector (HEPD) on board the CSES-01 Satellite between 2018 and 2020

Astrophysical Journal, 2020
The High-energy Particle Detector (HEPD) on board the China Seismo-Electromagnetic Satellite (CSES-01)—launched on 2018 February 2—is a light and compact payload suitable for measuring electrons (3–100 MeV), protons (30–250 MeV), and light nuclei (up to ...
S. Bartocci, R. Battiston, W. Burger, D. Campana, L. Carfora, G. Castellini, L. Conti, A. Contin, C. Donato, F. D. Persio, C. Santis, P. Diego, F. Follega, R. Iuppa, I. Lazzizzera, N. Marcelli, M. Martucci, G. Masciantonio, M. Mergé, G. Osteria, F. Palma, F. Palmonari, A. Parmentier, F. Perfetto, P. Picozza, M. Piersanti, M. Pozzato, I. Rashevskaya, E. Ricci, M. Ricci, S. Ricciarini, V. Scotti, A. Sotgiu, R. Sparvoli, P. Ubertini, V. Vitale, S. Zoffoli, P. Zuccon   +37 more
semanticscholar   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

SIFAT-SIFAT PAPAN PARTIKEL KAYU KELAPA

Jurnal Penelitian Hasil Hutan (Journal of Forest Products Research), 2017
This report  deals with the  laboratory  tests  on  the  properties of  particle board made  from  coconut  wood  and from  coconut wood with  hardwood bonded by urea formaldehyde.
Rozak Memed, Paribotro Sutigno, I M Sulastiningsih   +2 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source