Results 51 to 60 of about 76,537 (280)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Qualidade de chapas de partículas de Pinus elliottii coladas com resina poliuretana sob diferentes combinações de pressão e temperatura

Ciência Florestal, 2011
This work aimed to produce homogeneous layer particle boards with residues of Pinus elliottii wood adhered with polyurethane adhesive to castor oil plant base and to evaluate the effect of the combination of pressure and temperature in the quality of the
Juarez Benigno Paes, Shirley Tavares Nunes, Francisco Antônio Rocco Lahr, Maria de Fátima Nascimento, Roberta Maria de Albuquerque Lacerda   +4 more
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Recovery of valuable metals from waste printed circuit boards using organic acids synthesised by Aspergillus niveus

IET Nanobiotechnology, 2021
Organic acids such as citric acid, itaconic acid and oxalic acid synthesised by Aspergillus niveus were used for the bioleaching of metals from waste printed circuit boards.
Santhosh Krishnamoorthy, Gnanasekaran Ramakrishnan, Balaji Dhandapani   +2 more
doaj   +1 more source

Properties of particleboard manufactured from commonly utilized Malaysian bamboo (Gigantochloa scortechinii) [PDF]

, 2001
Buluh semantan (Gigantochloa scortechinii), one of the most widespread bamboo species in Peninsular Malaysia was investigated for its suitability as a raw material for particleboard production. A total of 120 bamboo culms from three different age group (
Ahmad, Abd. Jalil, Ashaari, Zaidon, Harun, Jalaludin, Kasim, Jamaludin, Mohd Yusoff, Mohd Nor, Mohmod, Abdul Latif   +5 more
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Effect of great size wood particles on density profile and physical -mechanical properties of particleboards made from poplar [PDF]

تحقیقات علوم چوب و کاغذ ایران, 2011
This study was conducted to investigate the effect of mixing great size wood particles of poplar with appropriate size particles of the same species, on density profile and physical -mechanical properties of the made particleboard, this study was carried
Ali akbar Enayati, Farnaz Eslah
doaj   +1 more source

Analysis of the Manufacturing Variables of Binderless Panels Made of Leaves of Olive Tree (Olea europaea L.) Pruning Waste

Agronomy, 2021
While the construction industry consumes more raw materials than any other industrial sector, agriculture generates a large amount of waste that is not managed properly.
Antonio Ferrandez-Garcia, Maria Teresa Ferrandez-Garcia, Teresa Garcia Ortuño, Francisco Mata-Cabrera, Manuel Ferrandez-Villena   +4 more
doaj   +1 more source

GRAPE-6: The massively-parallel special-purpose computer for astrophysical particle simulation

, 2003
In this paper, we describe the architecture and performance of the GRAPE-6 system, a massively-parallel special-purpose computer for astrophysical $N$-body simulations.
Fukushige, Toshiyuki, Koga, Masaki, Makino, Junichiro, Namura, Ken   +3 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source