Results 151 to 160 of about 169,131 (312)

Tomography of a Spatially Resolved Single-Atom Detector in the Presence of Shot-to-Shot Number Fluctuations

PRX Quantum
The tomography of single-particle-resolved detectors is of primary importance for characterizing particle correlations, with applications in quantum metrology, quantum simulation, and quantum computing. However, it is a nontrivial task in practice due to
Maxime Allemand, Raphael Jannin, Géraud Dupuy, Jan-Philipp Bureik, Luca Pezzè, Denis Boiron, David Clément   +6 more
doaj   +1 more source

The "Puck" energetic charged particle detector: Design, heritage, and advancements. [PDF]

J Geophys Res Space Phys, 2016
Clark G, Cohen I, Westlake JH, Andrews GB, Brandt P, Gold RE, Gkioulidou MA, Hacala R, Haggerty D, Hill ME, Ho GC, Jaskulek SE, Kollmann P, Mauk BH, McNutt RL, Mitchell DG, Nelson KS, Paranicas C, Paschalidis N, Schlemm CE.   +19 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Design studies of the muon detector for the SuperB experiment

, 2011
SuperB is one of the flagship projects of the Italian Govern and in 2010 has been approved. Starting from the Conceptual Design Report (CDR), now the collaboration is moving to the Technical Design Report (TDR). SuperB will be an asymmetric e+
Munerato, Mauro
core  

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Electronics for Particle Detectors

, 2009
In the previous chapters, we have seen that the detection of ionising radiation in the end nearly always comes down to detecting some small electrical signal. Dealing with such small signals is one of the main challenges in designing detectors for nuclear physics and particle physics. Photomultiplier tubes and gas amplification detectors such as Geiger
openaire   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source