Results 41 to 50 of about 64,617 (266)

Inducing the Effect of a Ga₂O₃ Nano-Particle on the CsF-RbF-AlF₃ Flux for Brazing Aluminum to Carbon Steels

Crystals, 2020
In this study, a Ga2O3 nano-particle was added into CsF-RbF-AlF3 flux to develop a highly active flux for brazing aluminum alloy to steel, and the spreadability and wettability of Zn-Al filler metal that matched the CsF-RbF-AlF3 flux-doped Ga2O3 nano ...
Zhen Yao, Songbai Xue, Jinlong Yang, Junxiong Zhang   +3 more
doaj   +1 more source

Trapped and Leaking Energetic Particles in Injection Flux Tubes of Saturn's Magnetosphere

Geophysical Research Letters, 2023
In Saturn's magnetosphere, the radially‐inward transport of magnetic fluxes is usually carried by localized flux tubes with sharply‐enhanced equatorial magnetic fields.
Ze‐Fan Yin, Yi‐Xin Sun, Xu‐Zhi Zhou, Dong‐Xiao Pan, Zhong‐Hua Yao, Chao Yue, Ze‐Jun Hu, Elias Roussos, Michel Blanc, Hai‐Rong Lai, Qiu‐Gang Zong   +10 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Gravity-Driven Flux of Particles through Apertures

Physical Review Letters
The gravity-driven discharge of granular material through an aperture is a fundamental problem in granular physics and is classically described by empirical laws with different fitting parameters. In this Letter, we disentangle the mass flux into distinct velocity and packing contributions by combining three-dimensional experiments and simulations.
Ram Sudhir Sharma, Alexandre Leonelli, Kevin Zhao, Eckart Meiburg, Alban Sauret   +4 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Spatiotemporal dynamics of snow erosion, deposition and horizontal mass flux

Journal of Glaciology, 2019
The quantification of snow transport, both in wind tunnels and the field, apply particle counting methods limited to punctual sampling of relatively small volumes. Particle counting can only capture horizontal mass fluxes, failing to measure snow erosion
PHILIP CRIVELLI, ENRICO PATERNA, MICHAEL LEHNING   +2 more
doaj   +1 more source