Results 101 to 110 of about 3,016,111 (298)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Effect of particle shape on silo discharge [PDF]
EPJ Web of ConferencesSilo discharge rate of rod-like and ellipsoidal particles is compared in laboratory experiments. We focus on how the flow rate is changing with particle aspect ratio a/b.
Börzsönyi Tamás +3 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Multi-scale analysis of the influence of particle shape on the mechanical response of granular materials [PDF]
, 2019 Particle-scale characteristics govern the behaviour of particulate materials at the macroscale. An important factor that dominates the interaction of individual particles is shape, which generates particle interlocking.
Soltanbeigi, Behzad
core +3 more sources
Shuili Shuiyun Gongcheng XuebaoRockfill material, as the primary construction material for earth-rock dams, exhibits dynamic deformation characteristics under seismic action that are influenced by particle shape, gradation, and relative density.
YANG Gui, LIU Yu, TANG Chenjing
doaj +1 more source
ELECTRODEPOSITION OF COPPER POWDER FROM MIXTURE SULPHATE –CHLORIDE ACIDIC SOLUTION
Iraqi Journal for Mechanical and Materials Engineering, 2018 This paper studies the preparation of Copper powder from Copper Sulphate aqueous solution(CuSO4.5H2O), sulfuric acid (H2SO4) and copper chloride (CuCl2.2H2O)by using the process of electro-deposition.
Sundus A Jasim
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Effect of Particle Shape on the Flow of an Hourglass
Physical Review LettersThe flow rate of a granulate out of a cylindrical container is studied as a function of particle shape for flat and elongated ellipsoids experimentally and numerically. We find a nonmonotonic dependence of the flow rate on the grain aspect ratio a/b.
Bo Fan +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source