Results 131 to 140 of about 291,283 (307)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

On Characterizing Particle Shape

, 2014
It is well known that particle shape affects flow characteristics of granular materials, as well as a variety of other solids processing issues such as compaction, rheology, filtration and other two-phase flow problems.
Rickman, Douglas, Ennis, Brandon, Rollins, A. Brent, Ennis, Bryan J.   +3 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A data extraction system for underwater particle holography

, 2000
Pulsed laser holography is an extremely powerful technique for the study of particle fields as it allows instantaneous, noninvasive high-resolution recording of substantial volumes.
Nebrensky, JJ, Craig, G, Lampitt, RS, Nareid, H, Trucco, A, Watson, J, Hobson, PR, Pescetto, A   +7 more
core  

Influence of Magnet Particle Shape on Magnetic and Environmental Stability of FDM Polymer-Bonded Magnets. [PDF]

Materials (Basel), 2023
Damnjanović A, Kovačević N.
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Impact of Particle Shape and Surface Group on Membrane Fouling. [PDF]

Membranes (Basel), 2022
Tanis-Kanbur MB, Tamilselvam NR, Lai HY, Chew JW.   +3 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Influence of shape on particle size analysis

, 1993
The purpose of this paper is to study the influence of the shape of the particles on the response of the instruments used for their measurement. This was achieved by sizing three different particle shape materials with three different particle sizers.
Rasteiro, M. G., Figueiredo, M. M., Ferreira, P. J.   +2 more
core   +1 more source

The effect of particle shape on discharge and clogging. [PDF]

Sci Rep, 2021
Hafez A, Liu Q, Finkbeiner T, Alouhali RA, Moellendick TE, Santamarina JC.   +5 more
europepmc   +1 more source