Results 51 to 60 of about 5,934,268 (299)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Shaping Particles for Ultramicrotomy [PDF]
MRS Proceedings, 1991 AbstractA technique for preshaping large particles of reacted glass for ultramicrotomy is described. This technique preserves delicate surface layers and results in more sections per block extending deeper into the sample than other techniques.
Bradley, C.R., Dietz, N.L., Bates, J.K.
openaire +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
KONA Powder and Particle Journal, 2014 A wet micro-feeder that utilizes ultrasonic wave force was designed and constructed to feed small particles into a container of wet particulate materials. The particle discharge characteristics from a nozzle with the
Kenichi Yamamoto +4 more
doaj +1 more source
Effect of Particle Size and Constraint Conditions on Single Particle Strength of Carbonate Sand
Sensors, 2022 Carbonate sand is often encountered and utilized as construction material in offshore engineering projects. Carbonate sand particles, which are porous and angular, are found to be highly crushable under high stress conditions, whereas the mechanisms and ...
Yong He, Guojun Cai, Lei Gao, Huan He
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Frontiers in Water, 2021 Many particulate pollutants in the environment exist in non-spherical shape, but the influences of particle shape on pollutant migration and removal in groundwater systems are not well-understood.
Ke Li, Huilian Ma
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Combining experiment and prediction to explore surface chemistry and dissolution
IUCrJA crystal structure is often an integral component in the development of a new pharmaceutical product, and these structures are frequently used to understand, assess and often predict both the manufacturing and in vivo behaviour of these compounds ...
Andrew G. P. Maloney
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Performance Parameters and Characterizations of Nanocrystals: A Brief Review
Pharmaceutics, 2016 Poor bioavailability of drugs associated with their poor solubility limits the clinical effectiveness of almost 40% of the newly discovered drug moieties.
Manasi M. Chogale +2 more
doaj +1 more source