Results 101 to 110 of about 4,620,104 (297)

Subphotospheric Emission from Short Gamma-Ray Bursts: Protons Mold the Multimessenger Signals

open access: yesThe Astrophysical Journal Letters
The origin of the observed Band-like photon spectrum in short gamma-ray bursts (sGRBs) is a long-standing mystery. We carry out the first general relativistic magnetohydrodynamic simulation of an sGRB jet with initial magnetization σ _0 = 150 in ...
Annika Rudolph   +2 more
doaj   +1 more source

Intra-community spatial variability of particulate matter size distributions in Southern California/Los Angeles [PDF]

open access: yesAtmospheric Chemistry and Physics, 2009
Ultrafine particle (UFP) number concentrations vary significantly on small spatial and temporal scales due to their short atmospheric lifetimes and multiplicity of sources.
M. Krudysz   +4 more
doaj  

Identification of Sediment Sources Based on Grain Size of Soil

open access: yesShuitu baochi yanjiu, 2023
[Objective] The research aims to reveal the influence of wind action on water erosion in the wind-water composite erosion area of the Loess Plateau, provide an effective method support for the identification of erosion material sources with different ...
LI Xiaozheng   +5 more
doaj  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

The cusp as a source of magnetospheric particles

open access: yesRadiation Measurements, 1999
Abstract Observations made by the Polar satellite have shown that plasma of solar wind/magnetosheath origin is rammed into the high altitude polar cusp creating a diamagnetic cavity of large dimensions. The Earth’s dipole field can be excluded from this region in a turbulent manner with the magnitude of the field strength reaching close to zero nT at
Theodore A Fritz, Jiasheng Chen
openaire   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Probing clustering in excited alpha-conjugate nuclei

open access: yesPhysics Letters B, 2016
The fragmentation of quasi-projectiles from the nuclear reaction 40Ca+12C at 25 MeV per nucleon bombarding energy was used to produce α-emission sources. From a careful selection of these sources provided by a complete detection and from comparisons with
B. Borderie   +26 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

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