Results 201 to 210 of about 162,068 (290)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Multiple Cutaneous Squamous Cell Carcinomas on Primary Epidermodysplasia Verruciformis in a 19-Year-Old Black Subject. [PDF]

Case Rep Dermatol Med
Kassang P, Mouhari-Toure A, Djiwa T, Akakpo SA, Teclessou JN, Saka B, Pitche P.   +6 more
europepmc   +1 more source

Particularity of Medical College Students’ Self-Awareness as Future Professionals

, 2019
Rano I. Sunnatova
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Too Late to Reverse: An Atypical Postpartum Case of Acute Necrotizing Pancreatitis with Refractory ARDS Despite ECMO Support. [PDF]

Life (Basel)
Veres M, Flamind Oltean S, Pascanu S, Butiulca M, Branea OE, Lazar AE, Grigorescu BL.   +6 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Bardet-Biedl syndrome: a rare cause of end-stage kidney disease. Case report. [PDF]

Ann Med Surg (Lond)
Bouchoual M, Dadi K, Cherradi I, Anibar S, Berrajaa M, Serbati N, El Ouazzani M, Jabrane M, El Minaoui M, Arrayhani M.   +9 more
europepmc   +1 more source

Particularities of reproduction and oogenesisin teleost fish compared to mammals [PDF]

, 2005
Bernard Jalabert
openalex   +1 more source

Classical Christology and Social Justice: Why the Divinity of Christ Matters [PDF]

, 2010
Hughson, Thomas
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source