Results 111 to 120 of about 68,019 (287)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The Social Logic of Bounded Partisanship in Germany: A Comparison of Veteran Citizens (West Germans), New Citizens (East Germans) and Immigrants [PDF]
That partisanship is bounded. Almost every West German, East German and immigrant never supports one or both of the major parties and most people vary support for their party by claiming no partisan preference.
Alan S. Zuckerman, Martin Kroh
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cogent Business & ManagementThis study investigates the moderating role of political party affiliation in the relationship between tax knowledge, service quality, and tax compliance.
George Nyantakyi +5 more
doaj +1 more source
Adequacy of Current Succession Law in Light of the Constitution and Policy Considerations [PDF]
, 2010 In this article, Gerald R. Ford’s counsel during Ford’s confirmation to the vice presidency under the Twenty-Fifth Amendment recounts the process, including investigations into Ford as part of the process and the confirmation hearings in the Senate and ...
Becker, Benton
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Mimicry or meltdown? On the greening of local new politics parties [PDF]
, 2011 By scrutinizing a specific type of local lists - interpreted as a local variant of ‘New Politics Parties’ - this paper aims to give an initial impetus to understanding the internal variations concealed by the all-purpose denominator of local lists. Local
Heyerick, An, Steyvers, Kristof
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Frontiers in PsychologyWe investigated how near-future utopia and dystopia scenarios affect electorates' valuation of the leading Finnish politicians in the multiparty democracy.
Janne Kauttonen, Jyrki Suomala
doaj +1 more source