Results 141 to 150 of about 365,196 (296)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Élaboration d'une nouvelle métaheuristique pour le partitionnement de graphe : la méthode de fusion-fission. Application au découpage de l'espace aérien [PDF]
, 2007 Dans cette thèse, nous étudions des méthodes de partitionnement de graphe et les appliquons au découpage de l'espace aérien, ainsi qu'à d'autres problèmes. L'espace aérien est composé de volumes limités, appelés secteurs de contrôle, chacun étant sous la
Bichot, Charles-Edmond
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
APPLICATION OF RECURSIVE PARTITIONING TO AGRICULTURAL CREDIT SCORING [PDF]
Recursive Partitioning Algorithm (RPA) is introduced as a technique for credit scoring analysis, which allows direct incorporation of misclassification costs.
Novak, Michael P., LaDue, Eddy L.
core
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
The logic of organizational markets: thinking through resource partitioning theory [PDF]
Resource partitioning theory claims that Increasing concentration enhances the life chances of specialist organizations. We systemati- cally think through this theory,specify implicit background assump- tions,sharpen concepts,and rigorously check the ...
Bruggeman, J., Vermeulen, I.
core
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Enabling error-resilient internet broadcasting using motion compensated spatial partitioning and packet FEC for the dirac video codec [PDF]
, 2008 Video transmission over the wireless or wired network require protection from channel errors since compressed video bitstreams are very sensitive to transmission errors because of the use of predictive coding and variable length coding. In this paper, a
Loo, KK, Tun, M, Cosmas, J
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source